Adverse cardiovascular events in coronary Plaques not undeRgoing pErcutaneous coronary intervention evaluateD with optIcal Coherence Tomography. The PREDICT-AI risk model.

Journal: Open heart
Published Date: Aug 26, 2025

Abstract

INTRODUCTION: Most acute coronary syndromes (ACS) originate from coronary plaques that are angiographically mild and not flow limiting. These lesions, often characterised by thin-cap fibroatheroma, large lipid cores and macrophage infiltration, are termed 'vulnerable plaques' and are associated with a heightened risk of future major adverse cardiovascular events (MACE). However, current imaging modalities lack robust predictive power, and treatment strategies for such plaques remain controversial.

Authors

  • Francesco Bruno
    Division of Cardiology, Cardiovascular and Thoracic Department, Molinette Hospital, Città della Salute e della Scienza, Turin, Italy.
  • Maddalena Immobile Molaro
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Michela Sperti
    PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy.
  • Francesco Bianchini
    Department of Philosophy and Communication Studies, University of Bologna, Italy. Electronic address: francesco.bianchini5@unibo.it.
  • Miao Chu
    School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Camilla Cardaci
    Dipartimento di Ingegneria Meccanica e Aerospaziale, Politecnico di Torino, Turin, Italy.
  • Wojciech Wańha
    Third Division of Cardiology, Medical University of Silesia, Katowice, Poland.
  • Paweł Gąsior
    Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.
  • Simone Zecchino
    Rivoli Hospital, Rivoli, Italy.
  • Marco Pavani
    Rivoli Hospital, Rivoli, Italy.
  • Rocco Vergallo
    Department of Internal Medicine and Medical Specialties (DIMI), Università di Genova, Genova, Italy.
  • Simone Biscaglia
    UO Cardiologia, Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant'Anna, Cona, Italy.
  • Enrico Cerrato
    Rivoli Hospital, Rivoli, Italy.
  • Gioel Gabrio Secco
    Interventional Cardiology, Univ Piemonte Orientale, Alessandria, Italy.
  • Marco Mennuni
    University Hospital Maggiore della Carità, Novara, Italy.
  • Massimo Mancone
    Department of Cardiovascular, Respiratory, Nephrological and Geriatrical Sciences, University of Rome La Sapienza, Roma, Italy.
  • Ovidio De Filippo
    Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy; Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Alessio Mattesini
    AOU Careggi, Florence, Italy.
  • Paolo Canova
    Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
  • Alberto Boi
    Azienda Ospedaliera Brotzu, Cagliari, Italy.
  • Fabrizio Ugo
    Interventional Cardiology, PO S Andrea di Vercelli, Vercelli, Italy.
  • Roberto Scarsini
    Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Francesco Costa
    Department of Neurosurgery, Humanitas Research Hospital, Rozzano, Italy.
  • Enrico Fabris
    Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Giacomo Puccini, 50, 34148 Trieste, Italy.
  • Gianluca Campo
    Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy.
  • Wojtek Wojakowski
    Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.
  • Umberto Morbiducci
    Polito BIO Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Marco Deriu
    Dipartimento di Ingegneria Meccanica e Aerospaziale, Politecnico di Torino, Turin, Italy.
  • Shengxian Tu
    Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University.
  • Raffaele Piccolo
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Fabrizio D'Ascenzo
    Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy; Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address: fabrizio.dascenzo@gmail.com.
  • Claudio Chiastra
    PoliTo(BIO)Med Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Francesco Burzotta
    Department of Cardiovascular Sciences, Università Cattolica Del Sacro Cuore, Rome, Italy.

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