Divergent biological pathways distinguish community-acquired pneumonia from COVID-19 despite similar plasma cytokine profiles.

Journal: Respiratory research
Published Date: Aug 31, 2025

Abstract

BACKGROUND: Pulmonary infections, ranging from mild respiratory issues to severe multiorgan failure, pose a major global health threat. The immune response in community-acquired pneumonia (CAP) and COVID-19 influences disease severity and outcomes, but molecular pathogenesis differs across pathogens. Comparisons of plasma cytokine profiles between CAP and COVID-19 are limited. Analyzing these profiles with machine learning and bioinformatics could reveal subtle patterns and improve our understanding of immune responses in both conditions.

Authors

  • Douglas D Fraser
    Lawson Health Research Institute, London Health Sciences Centre, London, ON, Canada.
  • Logan R Van Nynatten
    Critical Care Medicine, Western University, London, ON, Canada.
  • David Tweddell
    Computer Science, Western University, London, ON, Canada.
  • Mark Daley
    Computer Science, Western University, London, ON, Canada.
  • James A Russell

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