COVID-19 Vaccine Boosters in People With Multiple Sclerosis: Improved SARS-CoV-2 Cross-Variant Antibody Response and Prediction of Protection.

Journal: Neurology(R) neuroimmunology & neuroinflammation
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: Although disease-modifying therapies (DMTs) may suppress coronavirus disease 2019 (COVID-19) vaccine responses in people with multiple sclerosis (pwMS), limited data are available on the cumulative effect of additional boosters. Maturation of Spike immunoglobulin G (IgG) to target a greater diversity of SARS-CoV-2 variants, especially past the BA.1 variant, has not been reported. In addition, the prediction of variant-specific protection, given that Spike antibody testing is not performed routinely, remains a challenge. We, therefore, evaluated whether additional vaccine doses improved the breadth of cross-variant recognition to target emerging SARS-CoV-2 variants. Machine learning-based models were designed to predict variant-specific protection status.

Authors

  • Avani Yeola
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Samuel Houston
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Anupriya Aggarwal
    The Kirby Institute, The University of New South Wales, Sydney, Australia.
  • Rashmi Gamage
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Vicki E Maltby
    Department of Neurology, John Hunter Hospital, Newcastle, Australia.
  • Marzena J Fabis-Pedrini
    The Perron Institute for Neurological and Translational Science, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia.
  • Linh Le-Kavanagh
    The Perron Institute for Neurological and Translational Science, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia.
  • Vera Merheb
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Kristy Nguyen
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Fiona X Z Lee
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Susan Walters
    The Perron Institute for Neurological and Translational Science, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia.
  • Marinda Taha
    The University of Sydney, Brain and Mind Centre, Australia.
  • Annmaree O'Connell
    The University of Sydney, Brain and Mind Centre, Australia.
  • Vilija G Jokubaitis
    Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
  • Angie Roldan
    Department of Neurology, MSNI Service, Alfred Health, Melbourne, Australia.
  • Mastura Monif
    Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
  • Helmut Butzkueven
    Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
  • Sandeep Sampangi
    Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
  • Louise Rath
    Department of Neurology, MSNI Service, Alfred Health, Melbourne, Australia.
  • Katherine Fazzolari
    Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia.
  • Todd A Hardy
    Department of Neurology, Concord Repatriation General Hospital, University of Sydney, Australia.
  • Heidi N Beadnall
    The University of Sydney, Brain and Mind Centre, Australia.
  • Michael H Barnett
    The University of Sydney, Brain and Mind Centre, Australia.
  • Allan G Kermode
    The Perron Institute for Neurological and Translational Science, QEII Medical Centre, The University of Western Australia, Nedlands, WA, Australia.
  • Christopher Dwyer
    CORe, Department of Medicine, University of Melbourne, Australia; and.
  • Tomas Kalincik
    CORe Department of Medicine University of Melbourne Melbourne Australia.
  • Simon A Broadley
    Department of Neurology, Gold Coast Hospital and Griffith University, Australia.
  • Stuart G Turville
    The Kirby Institute, The University of New South Wales, Sydney, Australia.
  • Stephen W Reddel
    The University of Sydney, Brain and Mind Centre, Australia.
  • Sudarshini Ramanathan
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Jeannette Lechner-Scott
    Hunter Medical Research Institute, New Lambton Heights, NSW, Australia/School of Medicine and Public Health, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia/Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia.
  • Anneke Van Der Walt
    Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
  • Fabienne Brilot
    Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.