Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention.

Journal: The journal of prevention of Alzheimer's disease
Published Date: Jul 16, 2025

Abstract

BACKGROUND: Alzheimer's disease (AD) frequently co-occurs with depressive symptoms, exacerbating both cognitive decline and clinical complexity, yet the neural substrates linking this co-occurrence remain poorly understood. We aimed to investigate the role of basal forebrain-limbic system circuit dysregulation in the interaction between cognitive impairment and depressive symptoms, identifying potential biomarkers for early diagnosis and intervention.

Authors

  • Xiaowen Xu
    Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, PR China. Electronic address: xuxw@sdu.edu.cn.
  • Xiereniguli Anayiti
    Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200092, China.
  • Peiying Chen
    Department of Anesthesiology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Zhongfeng Xie
    Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200092, China.
  • Mengling Tao
    Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200092, China.
  • Yongsheng Xiang
    Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200092, China.
  • Mingyu Tan
    Radiology Department, Huadong Hospital, affiliated to Fudan University, Shanghai, China.
  • Yingying Liu
    Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Ling Yue
    Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Shifu Xiao
    Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Peijun Wang
    Department of Radiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, P.R. China.

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