Risk calculator for long-term survival prediction of spinal chordoma versus chondrosarcoma: a nationwide analysis.

Journal: Journal of neuro-oncology
Published Date:

Abstract

PURPOSE: Chordomas and chondrosarcomas are rare, aggressive spinal bone tumors with distinct origins, biological behavior, and treatment challenges, primarily due to their resistance to conventional chemotherapy and radiation. This study aimed to compare clinical characteristics, treatment strategies, and long-term outcomes between spinal chordoma and chondrosarcoma, and to develop a robust machine learning-based model for individualized survival prediction.

Authors

  • Abdul Karim Ghaith
    Mayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, Minnesota, USA; Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Xinlan Yang
    Department of Neurosurgery, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street/Meyer 5-181, Baltimore, MD, 21287, USA.
  • Abdel-Hameed Al-Mistarehi
    School of Medicine, Department of Neurosurgery, Johns Hopkins University, 600 N. Wolfe Street / Meyer 5-181, Baltimore, MD, 21287, USA.
  • Linda Tang
    Department of Neurosurgery, Johns Hopkins Medicine, Baltimore, MD, USA.
  • Nathan Kim
  • Joshua Weinberg
    School of Medicine, Department of Neurosurgery, Ohio State University, Columbus, OH, USA.
  • Jawad Khalifeh
    Department of Neurosurgery, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street/Meyer 5-181, Baltimore, MD, 21287, USA.
  • Yuanxuan Xia
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/Meyer 5-181, Baltimore, MD, 21287, USA.
  • Chase H Foster
    Department of Neurological Surgery, George Washington University, Washington, DC, USA.
  • Kristin Redmond
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Sang Lee
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/Meyer 5-181, Baltimore, MD, 21287, USA.
  • Majid Khan
    H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • David Xu
    Department of BioHealth Informatics, Indiana University School of Informatics and Computing , Indianapolis, Indiana 46202, United States.
  • Taha Khalilullah
    Department of Neurosurgery, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street/Meyer 5-181, Baltimore, MD, 21287, USA.
  • Khaled Zaitoun
    Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
  • Nicholas Theodore
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Orthopaedic Surgery & Biomedical Engineering, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: theodore@jhmi.edu.
  • Daniel Lubelski