Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.

Journal: International journal of chronic obstructive pulmonary disease
PMID: 29483774

Abstract

INTRODUCTION: The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. Determining systemic mediators may help clarify the nature of inflammation in patients with ACO.

Authors

  • Luis Pérez de Llano
    Department of Respiratory Medicine, Hospital Lucus Augusti, Lugo, Spain.
  • Borja G Cosío
    Department of Respiratory Medicine, Hospital Universitario Son Espases-IdISBa, Palma de Mallorca, Spain.
  • Amanda Iglesias
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Natividad de Las Cuevas
    Department of Allergy, Hospital 12 de Octubre, Madrid, Spain.
  • Juan Jose Soler-Cataluña
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Jose Luis Izquierdo
    Department of Respiratory Medicine, Hospital Universitario de Guadalajara, Guadalajara, Spain.
  • Jose Luis López-Campos
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Carmen Calero
    Department of Respiratory Medicine, Hospital Virgen del Rocío, Sevilla, Spain.
  • Vicente Plaza
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Marc Miravitlles
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Alfons Torrego
    Department of Respiratory Medicine, Hospital de la Santa Creu y Sant Pau, Barcelona, Spain.
  • Eva Martinez-Moragon
    Department of Respiratory Medicine, Hospital Dr Peset, Valencia, Spain.
  • Joan B Soriano
    Instituto de Investigación Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
  • Antolin Lopez Viña
    Department of Respiratory Medicine, Hospital Puerta de Hierro, Madrid, Spain.
  • Irina Bobolea
    Servei de Pneumologia i Alergia, Hospital Clinic, Barcelona, Spain.

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