AIMC Topic: Cell Adhesion Molecules

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A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with Zr/I-Labeled Tinurilimab.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Apr 3, 2025
Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application o...
Female Animals Cell Line, Tumor Lung Neoplasms Mice Humans Zirconium Cell Adhesion Molecules Radioisotopes Adenocarcinoma of Lung Theranostic Nanomedicine Antibodies, Monoclonal, Humanized Multiple Pulmonary Nodules Antibodies, Monoclonal Iodine Radioisotopes
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Utilizing machine learning to integrate single-cell and bulk RNA sequencing data for constructing and validating a novel cell adhesion molecules related prognostic model in gastric cancer.

Computers in biology and medicine Aug 12, 2024
BACKGROUND: Cell adhesion molecules (CAMs) play a vital role in cell-cell interactions, immune response modulation, and tumor cell migration. However, the unique role of CAMs in gastric cancer (GC) remains largely unexplored.
Humans Machine Learning Prognosis Cell Adhesion Molecules Middle Aged Single-Cell Analysis Sequence Analysis, RNA Gene Expression Regulation, Neoplastic Antigens, CD34 Female Stomach Neoplasms Biomarkers, Tumor Male
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Oral Cancer Prediction Using a Probability Neural Network (PNN).

Asian Pacific journal of cancer prevention : APJCP Sep 1, 2023
OBJECTIVE: In India, usually, oral cancer is mostly identified at a progressive stage of malignancy. Hence, we are motivated to identify oral cancer in its early stages, which helps to increase the lifetime of the patient, but this early detection is...
Humans Neural Networks, Computer Algorithms Cell Adhesion Molecules Wavelet Analysis India Nuclear Proteins Mouth Neoplasms Probability
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An Integrated Approach Fusing CEEMD Energy Entropy and Sparrow Search Algorithm-Based PNN for Fault Diagnosis of Rolling Bearings.

Computational intelligence and neuroscience Jul 22, 2022
This paper solves the problem of difficulty in achieving satisfactory results with traditional methods of bearing fault diagnosis, which can effectively extract the fault information and improve the fault diagnosis accuracy. This paper proposes a nov...
Entropy Vibration Artificial Intelligence Algorithms Nuclear Proteins Cell Adhesion Molecules Humans Neural Networks, Computer
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Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role.

Atherosclerosis Dec 24, 2018
BACKGROUND AND AIMS: The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and th...
Cytokines Peptidyl-Dipeptidase A Biomarkers Plaque, Atherosclerotic Female Animals Male Peptide Fragments Severity of Illness Index Cell Adhesion Molecules Humans Anti-Inflammatory Agents Angiotensin-Converting Enzyme 2 Case-Control Studies Cells, Cultured Coronary Artery Disease Chromogranin A Disease Models, Animal Atherosclerosis Mice, Knockout, ApoE Human Umbilical Vein Endothelial Cells Down-Regulation
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Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients.

AMIA ... Annual Symposium proceedings. AMIA Symposium Dec 5, 2018
Clusters of differentiation () are cell surface biomarkers that denote key biological differences between cell types and disease state. CD-targeting therapeutic monoclonal antibodies () afford rich trans-disease repositioning opportunities. Within a ...
Ki-1 Antigen Middle Aged Aged Sialic Acid Binding Ig-like Lectin 2 Cell Differentiation Case-Control Studies Young Adult Humans Lupus Erythematosus, Systemic Adolescent Adult Machine Learning Reference Values Male Child Biomarkers Antigens, CD20 Female Cell Adhesion Molecules
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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging.

Nature communications Apr 27, 2018
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called ...
Actin Cytoskeleton Intravital Microscopy Actin-Related Protein 2-3 Complex Microfilament Proteins Potoroidae Models, Biological Phosphoproteins Indoles Actins Cell Adhesion Molecules Humans Cell Line, Tumor Machine Learning Cell Movement Software Pseudopodia Cluster Analysis Animals Vasodilator-Stimulated Phosphoprotein Cell Line
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Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.

International journal of chronic obstructive pulmonary disease Feb 12, 2018
INTRODUCTION: The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. D...
Interleukin-6 Biomarkers Prognosis Female Aged Adult Pulmonary Disease, Chronic Obstructive Asthma Cross-Sectional Studies Spain Humans Vital Capacity Neural Networks, Computer Interleukin-13 Tumor Necrosis Factor-alpha Interleukin-5 Th2 Cells Interleukin-8 Male Discriminant Analysis Middle Aged Forced Expiratory Volume Lung Inflammation Mediators Interleukin-17 Cell Adhesion Molecules
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Machine Learning Models Based on Stretched-Exponential Diffusion Weighted Imaging to Predict TROP2 Expression in Nude Mouse Breast Cancer Models.

Discovery medicine Mar 1, 2025
BACKGROUND: Trophoblast cell surface antigen 2 (TROP2) is a promising target for various cancers, including breast cancer. The development of noninvasive techniques for assessing TROP2 expression in tumors holds considerable importance. This study ai...
Mice, Nude Cell Adhesion Molecules Diffusion Magnetic Resonance Imaging Humans Machine Learning Breast Neoplasms Female Animals Mice Antigens, Neoplasm Disease Models, Animal
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