On differentiation between vasogenic edema and non-enhancing tumor in high-grade glioma patients using a support vector machine classifier based upon pre and post-surgery MRI images.

Journal: European journal of radiology
Published Date: Sep 1, 2018

Abstract

PURPOSE: High grade gliomas (HGGs) are infiltrative in nature. Differentiation between vasogenic edema and non-contrast enhancing tumor is difficult as both appear hyperintense in T-W/FLAIR images. Most studies involving differentiation between vasogenic edema and non-enhancing tumor consider radiologist-based tumor delineation as the ground truth. However, analysis by a radiologist can be subjective and there remain both inter- and intra-rater differences. The objective of the current study is to develop a methodology for differentiation between non-enhancing tumor and vasogenic edema in HGG patients based on T perfusion MRI parameters, using a ground truth which is independent of a radiologist's manual delineation of the tumor.

Authors

  • Anirban Sengupta
    Centre for Biomedical Engineering, IIT Delhi, New Delhi, India.
  • Sumeet Agarwal
    Department of Electrical Engineering, IIT Delhi, New Delhi, India.
  • Pradeep Kumar Gupta
    Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India.
  • Sunita Ahlawat
    SRL Diagnostics, Fortis Memorial Research Institute, Gurgaon, India.
  • Rana Patir
    Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India.
  • Rakesh Kumar Gupta
    Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India.
  • Anup Singh
    Centre for Biomedical Engineering, IIT Delhi, New Delhi, India; Department of Biomedical Engineering, AIIMS Delhi, New Delhi, India. Electronic address: anupsm@iitd.ac.in.

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