Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Journal: Pain research & management
PMID: 30651902

Abstract

BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate chronic radiculitis and mechanical allodynia after noncompressive lumbar disc herniation and at elucidating the underlying mechanisms.

Authors

  • Junnan Wang
    Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, China.
  • Mingyi Wu
    Department of Anesthesiology, Shandong Provincial Corps Hospital of Chinese People's Armed Police Forces, Jinan, Shandong 250014, China.
  • Xiaowen Lin
    Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, China.
  • Yun Li
    School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Zhijian Fu
    Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, China.

Keywords

External Resources

Popular Topics
Recent Journals