AIMC Topic: Transcription Factor RelA

Clear Filters Showing 1 to 5 of 5 articles

Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.

Archives of toxicology Jun 12, 2020
Accurate prediction of drug- and chemical-induced hepatotoxicity remains to be a problem for pharmaceutical companies as well as other industries and regulators. The goal of the current study was to develop an in vitro/in silico method for the rapid ...
DNA Damage Microscopy, Fluorescence Hep G2 Cells Dose-Response Relationship, Drug Hepatocytes High-Throughput Screening Assays Toxicity Tests Cellular Senescence Cell Death Humans Machine Learning Risk Assessment Image Processing, Computer-Assisted Phenotype Proto-Oncogene Mas Primary Cell Culture Actin Cytoskeleton Transcription Factor RelA Chemical and Drug Induced Liver Injury
View on PubMed DOI

Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Pain research & management Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Radiculopathy Intervertebral Disc Displacement Ozone NF-kappa B Cyclic Nucleotide Phosphodiesterases, Type 2 Cyclic AMP Hyperalgesia Cyclic GMP Transcription Factor RelA Signal Transduction Rats, Wistar Animals Disease Models, Animal Treatment Outcome Rats Male Oxygen
View on PubMed DOI

Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Gene Expression Signal Transduction Osteoarthritis Tissue Inhibitor of Metalloproteinase-1 Chondrocytes Interleukin-1beta NF-kappa B Matrix Metalloproteinases Humans Garlic Transcription Factor RelA Tumor Necrosis Factor-alpha Collagen Type II Cysteine
View on PubMed DOI

Identification of biomarkers associated with inflammatory response in Parkinson's disease by bioinformatics and machine learning.

PloS one Jan 1, 2025
Parkinson's disease (PD) is a common and debilitating neurodegenerative disorder. The inflammatory response is essential in the pathogenesis and progression of PD. The goal of this study is to combine bioinformatics and machine learning to screen for...
Gene Regulatory Networks Computational Biology Transcriptome Humans Protein Interaction Maps Parkinson Disease Biomarkers MicroRNAs Gene Expression Profiling Machine Learning Transcription Factor RelA RNA, Messenger Inflammation
View on PubMed DOI

[The Protective Effect of Inhibition of PARP-1 on Inflammation Induced by PM2.5 in Human Bronchial Epithelial Cell Line.].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Nov 1, 2016
OBJECTIVES: To explore whether the inhibition of poly ADP-ribose polymerase-1(PARP-1) could attenuated inflammation induced by fine particulate matter (PM2.5) in human bronchial epithelial cell line.
Transcription Factor RelA Humans Poly (ADP-Ribose) Polymerase-1 Particulate Matter Nitric Oxide Synthase Type II Nitric Oxide Inflammation Epithelial Cells
View on PubMed
Popular Topics
Recent Journals