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Transcription Factor RelA

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Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Pain research & management 30651902
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Animals Cyclic AMP Cyclic GMP Cyclic Nucleotide Phosphodiesterases, Type 2 Disease Models, Animal Hyperalgesia Intervertebral Disc Displacement Male NF-kappa B Oxygen Ozone Radiculopathy Rats Rats, Wistar Signal Transduction Transcription Factor RelA Treatment Outcome
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Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.

BioMed research international 29333456
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Chondrocytes Collagen Type II Cysteine Garlic Gene Expression Humans Interleukin-1beta Matrix Metalloproteinases NF-kappa B Osteoarthritis Signal Transduction Tissue Inhibitor of Metalloproteinase-1 Transcription Factor RelA Tumor Necrosis Factor-alpha
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[The Protective Effect of Inhibition of PARP-1 on Inflammation Induced by PM2.5 in Human Bronchial Epithelial Cell Line.].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 28598106
OBJECTIVES: To explore whether the inhibition of poly ADP-ribose polymerase-1(PARP-1) could attenuated inflammation induced by fine particulate matter (PM2.5) in human bronchial epithelial cell line.
Epithelial Cells Humans Inflammation Nitric Oxide Nitric Oxide Synthase Type II Particulate Matter Poly (ADP-Ribose) Polymerase-1 Transcription Factor RelA
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Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.

Archives of toxicology 32533217
Accurate prediction of drug- and chemical-induced hepatotoxicity remains to be a problem for pharmaceutical companies as well as other industries and regulators. The goal of the current study was to develop an in vitro/in silico method for the rapid ...
Actin Cytoskeleton Cell Death Cellular Senescence Chemical and Drug Induced Liver Injury DNA Damage Dose-Response Relationship, Drug Hep G2 Cells Hepatocytes High-Throughput Screening Assays Humans Image Processing, Computer-Assisted Machine Learning Microscopy, Fluorescence Phenotype Primary Cell Culture Proto-Oncogene Mas Risk Assessment Toxicity Tests Transcription Factor RelA
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