CPT: pharmacometrics & systems pharmacology
Dec 8, 2022
As formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic f...
CPT: pharmacometrics & systems pharmacology
Nov 8, 2022
Missing data create challenges in clinical research because they lead to loss of statistical power and potentially to biased results. Missing covariate data must be handled with suitable approaches to prepare datasets for pharmacometric analyses, suc...
CPT: pharmacometrics & systems pharmacology
Oct 20, 2022
The application of logistic regression (LR) and Cox Proportional Hazard (CoxPH) models are well-established for evaluating exposure-response (E-R) relationship in large molecule oncology drugs. However, applying machine learning (ML) models on evalua...
CPT: pharmacometrics & systems pharmacology
Oct 12, 2022
The gold-standard approach for modeling pharmacokinetic mediated drug-drug interactions is the use of physiologically-based pharmacokinetic modeling and population pharmacokinetics. However, these models require extensive amounts of drug-specific dat...
CPT: pharmacometrics & systems pharmacology
May 27, 2022
Nonlinear mixed effect (NLME) models are the gold standard for the analysis of patient response following drug exposure. However, these types of models are complex and time-consuming to develop. There is great interest in the adoption of machine-lear...
CPT: pharmacometrics & systems pharmacology
May 18, 2022
Pharmacometrics and the application of population pharmacokinetic (PK) modeling play a crucial role in clinical pharmacology. These methods, which describe data with well-defined equations and estimate physiologically interpretable parameters, have n...
CPT: pharmacometrics & systems pharmacology
Dec 9, 2021
Warfarin remains the most widely prescribed oral anticoagulant in sub-Saharan Africa. However, because of its narrow therapeutic index, dosing can be challenging. We have therefore (a) evaluated and compared the performance of 21 machine-learning tec...
CPT: pharmacometrics & systems pharmacology
Oct 30, 2021
Heterogeneous treatment effect (HTE) analysis focuses on examining varying treatment effects for individuals or subgroups in a population. For example, an HTE-informed understanding can critically guide physicians to individualize the medical treatme...