AIMC Topic: Simvastatin

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Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

CPT: pharmacometrics & systems pharmacology Dec 9, 2021
Warfarin remains the most widely prescribed oral anticoagulant in sub-Saharan Africa. However, because of its narrow therapeutic index, dosing can be challenging. We have therefore (a) evaluated and compared the performance of 21 machine-learning tec...
Humans Machine Learning International Normalized Ratio Models, Biological Anticoagulants Warfarin Africa South of the Sahara Male Drug Dosage Calculations Simvastatin Middle Aged Body Weight HIV Infections Sex Factors Age Factors Reproducibility of Results Adult Algorithms Female
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A novel integrated action crossing method for drug-drug interaction prediction in non-communicable diseases.

Computer methods and programs in biomedicine Jun 22, 2018
BACKGROUND AND OBJECTIVE: Drug-drug interaction (DDI) is one of the main causes of toxicity and treatment inefficacy. This work focuses on non-communicable diseases (NCDs), the non-transmissible and long-lasting diseases since they are the leading ca...
Probability Cytochrome P-450 Enzyme System Noncommunicable Diseases Drug Interactions Quantitative Structure-Activity Relationship Simvastatin False Positive Reactions Reproducibility of Results Support Vector Machine Humans Cluster Analysis Neural Networks, Computer Area Under Curve Databases, Factual Computer Simulation Machine Learning Algorithms
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Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.

Acta biomaterialia Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Human Umbilical Vein Endothelial Cells Alkaline Phosphatase Mesenchymal Stem Cells Neovascularization, Physiologic Dental Pulp Cytoprotection Humans Cell Differentiation Tissue Scaffolds Nanofibers Signal Transduction RNA, Messenger Simvastatin Biomarkers Lipopolysaccharides Polyesters Inflammation Odontogenesis Young Adult Gene Expression Regulation
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Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Statins have been widely used in acute pulmonary embolism (APE), while simvastatin has been well-established for the prevention of pulmonary hypertension, which was supposed to be an attractive recommendation for APE treatment.
Sirtuin 2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Treatment Outcome Simvastatin NF-kappa B Rats Rats, Sprague-Dawley Animals Pulmonary Embolism Male Signal Transduction
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