AIMC Topic: Simvastatin

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HMGCR-driven cholesterol metabolism dysregulation and its role in osteoarthritis diagnosis and immune regulation.

Biochemical and biophysical research communications Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Biomarkers Signal Transduction Synovial Membrane Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Simvastatin Hydroxymethylglutaryl CoA Reductases NF-kappa B Cholesterol Osteoarthritis
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Thermodynamic analysis and intelligent modeling of statin drugs solubility in supercritical carbon dioxide.

Scientific reports Aug 2, 2025
Evaluating the solubility of various drugs in supercritical CO is a fundamental step in developing a supercritical process for formulating new pharmaceuticals. Atorvastatin, Lovastatin, and Simvastatin are statin drugs with limited solubility and low...
Machine Learning Thermodynamics Carbon Dioxide Hydroxymethylglutaryl-CoA Reductase Inhibitors Solubility Simvastatin Atorvastatin Neural Networks, Computer
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Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

CPT: pharmacometrics & systems pharmacology Dec 9, 2021
Warfarin remains the most widely prescribed oral anticoagulant in sub-Saharan Africa. However, because of its narrow therapeutic index, dosing can be challenging. We have therefore (a) evaluated and compared the performance of 21 machine-learning tec...
Male Middle Aged HIV Infections Reproducibility of Results Adult International Normalized Ratio Models, Biological Body Weight Age Factors Anticoagulants Warfarin Humans Machine Learning Algorithms Female Drug Dosage Calculations Simvastatin Sex Factors Africa South of the Sahara
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A novel integrated action crossing method for drug-drug interaction prediction in non-communicable diseases.

Computer methods and programs in biomedicine Jun 22, 2018
BACKGROUND AND OBJECTIVE: Drug-drug interaction (DDI) is one of the main causes of toxicity and treatment inefficacy. This work focuses on non-communicable diseases (NCDs), the non-transmissible and long-lasting diseases since they are the leading ca...
Quantitative Structure-Activity Relationship Cytochrome P-450 Enzyme System Simvastatin False Positive Reactions Drug Interactions Computer Simulation Probability Reproducibility of Results Support Vector Machine Cluster Analysis Area Under Curve Noncommunicable Diseases Machine Learning Algorithms Databases, Factual Humans Neural Networks, Computer
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Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.

Acta biomaterialia Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Biomarkers Tissue Scaffolds Young Adult Simvastatin Neovascularization, Physiologic Dental Pulp RNA, Messenger Polyesters Cytoprotection Cell Differentiation Gene Expression Regulation Humans Nanofibers Human Umbilical Vein Endothelial Cells Alkaline Phosphatase Odontogenesis Inflammation Mesenchymal Stem Cells Signal Transduction Lipopolysaccharides
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Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Statins have been widely used in acute pulmonary embolism (APE), while simvastatin has been well-established for the prevention of pulmonary hypertension, which was supposed to be an attractive recommendation for APE treatment.
Sirtuin 2 Rats, Sprague-Dawley Rats Pulmonary Embolism NF-kappa B Animals Signal Transduction Hydroxymethylglutaryl-CoA Reductase Inhibitors Treatment Outcome Male Simvastatin
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