The field of nanomedicine has made substantial strides in the areas of therapeutic and diagnostic development. For example, nanoparticle-modified drug compounds and imaging agents have resulted in markedly enhanced treatment outcomes and contrast eff...
INTRODUCTION: Contrast induced nephropathy is linked to contrast utilization and strategies for minimizing renal injury are incorporated into many laboratories that perform coronary angiography. Contrast limits have been described, below which there ...
Individuals with type 1 diabetes have to monitor their blood glucose levels, determine the quantity of insulin required to achieve optimal glycaemic control and administer it themselves subcutaneously, multiple times per day. To help with this proces...
Medication doses, one of the determining factors in medication safety and effectiveness, are present in the literature, but only in free-text form. We set out to determine if the systems developed for extracting drug prescription information from cli...
In this paper, a reinforcement learning (RL)-based optimal adaptive control approach is proposed for the continuous infusion of a sedative drug to maintain a required level of sedation. To illustrate the proposed method, we use the common anesthetic ...
Journal of pharmacokinetics and pharmacodynamics
32812097
Despite the common approach of bolus drug dosing using a patient's mass, a more tailored approach would be to use empirically derived pharmacokinetic models. Previously, this could only be possible though the use of computer simulation using programs...
The first aim of this study was to develop a prothrombin time international normalized ratio (PT INR) prediction model. The second aim was to develop a warfarin maintenance dose decision support system as a precise warfarin dosing platform. Data of 1...
CPT: pharmacometrics & systems pharmacology
34270885
Model-informed precision dosing (MIPD) approaches typically apply maximum a posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) parameters with the goal of optimizing future dosing regimens. This process combines knowled...
CPT: pharmacometrics & systems pharmacology
34889080
Warfarin remains the most widely prescribed oral anticoagulant in sub-Saharan Africa. However, because of its narrow therapeutic index, dosing can be challenging. We have therefore (a) evaluated and compared the performance of 21 machine-learning tec...
Studies in health technology and informatics
39575809
Technology in the medical field is continuously advancing due to its numerous subdomains and the ever-growing medical needs of people. Information systems have become integral to doctors' daily routines in patient care, offering flexibility and suppo...