AI Medical Compendium Journal:
Cell communication and signaling : CCS

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Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer.

Cell communication and signaling : CCS Apr 5, 2025
BACKGROUND: Lysyl oxidases (LOX/LOXL1-4) are crucial for cancer progression, yet their transcriptional regulation, potential therapeutic targeting, prognostic value and involvement in immune regulation remain poorly understood. This study comprehensi...
Humans Machine Learning Computer Simulation Prognosis Neoplasms Computational Biology Gene Expression Regulation, Neoplastic Protein-Lysine 6-Oxidase
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Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth.

Cell communication and signaling : CCS Dec 5, 2024
BACKGROUND: Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression. Identification of new selec...
Humans Machine Learning Animals Antineoplastic Agents Cell Line, Tumor Lung Neoplasms Mice Cell Proliferation Signal Transduction Carcinoma, Non-Small-Cell Lung Mice, Nude Apoptosis Mutation Xenograft Model Antitumor Assays ErbB Receptors Protein Kinase Inhibitors Oleanolic Acid
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