AIMC Topic: 5-Methylcytosine

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ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine.

Nucleic acids research
Since the discovery of 5-hydroxymethylcytosine (5hmC) as a prominent DNA modification found in mammalian genomes, an emergent question has been what role this mark plays in gene regulation. 5hmC is hypothesized to function as an intermediate in the d...

DIRECTION: a machine learning framework for predicting and characterizing DNA methylation and hydroxymethylation in mammalian genomes.

Bioinformatics (Oxford, England)
MOTIVATION: 5-Methylcytosine and 5-Hydroxymethylcytosine in DNA are major epigenetic modifications known to significantly alter mammalian gene expression. High-throughput assays to detect these modifications are expensive, labor-intensive, unfeasible...

Identifying RNA 5-methylcytosine sites via pseudo nucleotide compositions.

Molecular bioSystems
RNA 5-methylcytosine (mC) plays an important role in numerous biological processes. Accurate identification of the mC site is helpful for a better understanding of its biological functions. However, the drawbacks of the experimental methods available...