AIMC Topic: Acylation

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Prediction of lysine formylation sites using support vector machine based on the sample selection from majority classes and synthetic minority over-sampling techniques.

Biochimie Oct 7, 2021
Lysine formylation is a newly discovered and mostly interested type of post-translational modification (PTM) that is generally found on core and linker histone proteins of prokaryote and eukaryote and plays various important roles on the regulation o...
Humans Animals Histones Acylation Protein Processing, Post-Translational Lysine Support Vector Machine
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HybridSucc: A Hybrid-learning Architecture for General and Species-specific Succinylation Site Prediction.

Genomics, proteomics & bioinformatics Aug 28, 2020
As an important protein acylation modification, lysine succinylation (Ksucc) is involved in diverse biological processes, and participates in human tumorigenesis. Here, we collected 26,243 non-redundant known Ksucc sites from 13 species as the benchm...
Acylation Lysine Succinic Acid Species Specificity Proteome Proteins Humans Area Under Curve Machine Learning Amino Acid Sequence Algorithms Neoplasms ROC Curve
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Prediction of lysine glutarylation sites by maximum relevance minimum redundancy feature selection.

Analytical biochemistry Apr 8, 2018
Lysine glutarylation is new type of protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of glutarylation, it is important to identify glutarylated substrates and their corresponding glutaryl...
Glutarates Sequence Analysis, Protein Acylation Proteins Lysine Software Protein Processing, Post-Translational Support Vector Machine
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Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation.

BioMed research international Oct 27, 2015
Reversible posttranslational modification (PTM) plays a very important role in biological process by changing properties of proteins. As many proteins are multiply modified by PTMs, cross talk of PTMs is becoming an intriguing topic and draws much at...
Dogs Rats Gene Ontology Protein Processing, Post-Translational Phosphorylation Evolution, Molecular Animals Humans Proteins Amino Acid Motifs Mice Acylation
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Modeling Enzyme Reaction and Mutation by Direct Machine Learning/Molecular Mechanics Simulations.

Journal of chemical theory and computation May 13, 2025
Accurately modeling enzyme reactions through direct machine learning/molecular mechanics simulations remains challenging in describing the electrostatic coupling between the QM and MM subsystems. In this work, we proposed a reweighting ME (mechanic e...
Aspirin Static Electricity Humans Mutation Machine Learning Molecular Dynamics Simulation Acylation Cyclooxygenase 1 Cyclooxygenase 2 Thermodynamics
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Deep-Kcr: accurate detection of lysine crotonylation sites using deep learning method.

Briefings in bioinformatics Jul 20, 2021
As a newly discovered protein posttranslational modification, histone lysine crotonylation (Kcr) involved in cellular regulation and human diseases. Various proteomics technologies have been developed to detect Kcr sites. However, experimental approa...
Lysine Sequence Analysis, Protein Databases, Protein Acylation Crotonates Humans Deep Learning Protein Processing, Post-Translational
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