AIMC Topic: alpha-Thalassemia

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Multiclass classification of thalassemia types using complete blood count and HPLC data with machine learning.

Scientific reports Jul 21, 2025
Mild to severe anemia is caused by thalassemia, a common genetic disorder affecting over 100 countries worldwide, that results from the abnormality of one or several of the four globin genes. This leads to chronic hemolytic anemia and disrupted synth...
Humans Machine Learning Support Vector Machine Chromatography, High Pressure Liquid Pakistan beta-Thalassemia Thalassemia alpha-Thalassemia Blood Cell Count
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A comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.

Scientific reports Apr 17, 2025
This study explores the performance of deep learning models, specifically Convolutional Neural Networks (CNN) and XGBoost, in predicting alpha and beta thalassemia using both public and private datasets. Thalassemia is a genetic disorder that impairs...
Humans Neural Networks, Computer Databases, Factual Deep Learning beta-Thalassemia alpha-Thalassemia
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Classification of α-thalassemia data using machine learning models.

Computer methods and programs in biomedicine Jan 6, 2025
BACKGROUND: Around 7% of the global population has congenital hemoglobin disorders, with over 300,000 new cases of α-thalassemia annually. Diagnosis is costly and inaccurate in low-income regions, often relying on complete blood count (CBC) tests. Th...
Humans Neural Networks, Computer Machine Learning Female Adult Male ROC Curve Sri Lanka Area Under Curve alpha-Thalassemia Blood Cell Count
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Support Vector Machine-Based Formula for Detecting Suspected α Thalassemia Carriers: A Path toward Universal Screening.

International journal of molecular sciences Jun 11, 2024
The blood counts of α thalassemia carriers (α-thal) are similar to those of β thalassemia carriers, except for Hemoglobin A (Hb A), which is not elevated. The objective of this study was to determine whether mathematical formulas are effective for de...
Humans Female Male Support Vector Machine Erythrocyte Indices beta-Thalassemia alpha-Thalassemia Heterozygote Genetic Carrier Screening
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Profiling of 35 Cases of Hb S/Hb E (: c.20A>T/: c.79G>a), Disease and Association with α-Thalassemia and β-Globin Gene Cluster Haplotypes from Odisha, India.

Hemoglobin Mar 4, 2022
Hb S/Hb E (: c.20A>T/: c.79G>A) is an uncommon variant of sickle cell disease resulting from coinheritance of Hb S and Hb E. Clinico-hematological and biochemical parameters of 35 cases of Hb S/Hb E disease were studied and compared with 70 matched c...
Humans beta-Thalassemia Anemia, Sickle Cell Haplotypes Multigene Family alpha-Thalassemia beta-Globins
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