AIMC Topic: Aporphines

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Nuciferine activates intestinal TAS2R46 to attenuate metabolic disorders and hyperlipidemia via hepatic VLDL regulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology Apr 22, 2025
BACKGROUND: Dysregulated blood lipid metabolism, a primary driver of hyperlipidemia, is closely associated with excessive very low-density lipoprotein (VLDL) synthesis and secretion. Nuciferine, a bioactive compound isolated from lotus leaves, demons...
Animals Male Molecular Docking Simulation Rats Rats, Sprague-Dawley Liver Diet, High-Fat Receptors, G-Protein-Coupled Lipid Metabolism Hyperlipidemias Hypolipidemic Agents Metabolic Diseases Aporphines Lipoproteins, VLDL
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HPLC-MS/MS method for the determination and pharmacokinetic study of six compounds against rheumatoid arthritis in rat plasma after oral administration of the extract of Caulophyllum robustum Maxim.

Journal of pharmaceutical and biomedical analysis Oct 21, 2019
Caulophyllum robustum Maxim (CRM) is a well-known traditional Chinese medicine (TCM) mainly present in the northeast, northwest and southwest regions of China, which is belong to the family Berberidaceae. The roots and rhizomes of CRM have been used ...
Animals Male Plant Extracts Rats Drugs, Chinese Herbal Triterpenes Chromatography, High Pressure Liquid Tandem Mass Spectrometry Spectrometry, Mass, Electrospray Ionization Aporphines Caulophyllum
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