AIMC Topic: bcl-2 Homologous Antagonist-Killer Protein

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Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitor.

Biochemical and biophysical research communications Dec 20, 2021
Apoptosis plays an essential role in maintaining cellular homeostasis and preventing cancer progression. Bcl-xL, an anti-apoptotic protein, is an important modulator of the mitochondrial apoptosis pathway and is a promising target for anticancer ther...
Humans Artificial Intelligence Neoplasms Molecular Docking Simulation Antineoplastic Agents Protein Binding Cell Proliferation Apoptosis Cell Line Pyridines Imines bcl-X Protein bcl-2 Homologous Antagonist-Killer Protein
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Structural Comparison of Gene Relevance Networks for Breast Cancer Tissues in Different Grades.

Combinatorial chemistry & high throughput screening Jan 1, 2016
BACKGROUND: The breast is an important biological system of human with two distinct states, i.e. normal and tumoral. Research on breast cancer could be based on systematic modeling to contrast the system structures of these two states.
Humans Female Breast Neoplasms Gene Regulatory Networks Support Vector Machine Lipocalin-2 ErbB Receptors ras Proteins Genes, Neoplasm Proto-Oncogene Proteins c-fos ZAP-70 Protein-Tyrosine Kinase bcl-2 Homologous Antagonist-Killer Protein
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