AIMC Topic: bcl-X Protein

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Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitor.

Biochemical and biophysical research communications Dec 20, 2021
Apoptosis plays an essential role in maintaining cellular homeostasis and preventing cancer progression. Bcl-xL, an anti-apoptotic protein, is an important modulator of the mitochondrial apoptosis pathway and is a promising target for anticancer ther...
Apoptosis Cell Line Cell Proliferation bcl-X Protein bcl-2 Homologous Antagonist-Killer Protein Pyridines Imines Neoplasms Molecular Docking Simulation Antineoplastic Agents Protein Binding Humans Artificial Intelligence
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A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data.

BMC medical genomics Oct 30, 2019
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most common subtype of neurodegenerative dementia in humans following Alzheimer's disease (AD). Present clinical diagnosis of DLB has high specificity and low sensitivity and finding potential...
Genetic Association Studies Signal Transduction Polymorphism, Single Nucleotide Lewy Body Disease Risk MicroRNAs Phosphatidylinositol 3-Kinases Aged Male Case-Control Studies Dementia Biomarkers Female Machine Learning bcl-X Protein Humans
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Tumor Suppressor Protein p53 Gene Expression Regulation Caspase 3 Proliferating Cell Nuclear Antigen Anti-Inflammatory Agents, Non-Steroidal Rats Achyranthes Cyclooxygenase 2 Apoptosis Inflammation bcl-Associated Death Protein Chondrocytes NF-kappa B Signal Transduction Saponins bcl-X Protein Matrix Metalloproteinase 9 Rats, Sprague-Dawley bcl-2-Associated X Protein Plant Roots Matrix Metalloproteinase 3 Male Cartilage, Articular Interleukin-1beta Primary Cell Culture Plant Extracts Animals
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