AIMC Topic: beta-Lactamases

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Antimicrobial activity of ceftazidime-avibactam and comparator agents when tested against bacterial isolates causing infection in cancer patients (2013-2014).

Diagnostic microbiology and infectious disease Nov 29, 2016
We evaluated the antimicrobial susceptibility of 623 Gram-negative organisms causing infection in patients with cancer in 52 United States hospitals (2013-2014) as part of the International Network for Optimal Resistance Monitoring (INFORM) program. ...
Pseudomonas aeruginosa Meropenem Colistin Enterobacter cloacae Escherichia coli beta-Lactamases Klebsiella pneumoniae Drug Combinations Neoplasms Microbial Sensitivity Tests Ceftazidime Drug Resistance, Multiple, Bacterial Humans Thienamycins Anti-Bacterial Agents Amikacin Azabicyclo Compounds
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In vitro activities and detection performances of cefmetazole and flomoxef for extended-spectrum β-lactamase and plasmid-mediated AmpC β-lactamase-producing Enterobacteriaceae.

Diagnostic microbiology and infectious disease Dec 11, 2015
To investigate the in vitro activities of cephamycins (cefmetazole and flomoxef) for extended-spectrum β-lactamase (ESBL)- and plasmid-mediated AmpC β-lactamase (pAmpC)-producing Enterobacteriaceae, a total of 574 third-generation cephalosporin-resis...
Polymerase Chain Reaction Enterobacteriaceae Infections Cefmetazole beta-Lactam Resistance Enterobacteriaceae Cephalosporins beta-Lactamases Japan Humans Anti-Bacterial Agents Genotype Sequence Analysis, DNA Microbial Sensitivity Tests
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Prediction of β-lactamase and its class by Chou's pseudo-amino acid composition and support vector machine.

Journal of theoretical biology Oct 22, 2014
β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic microbes. The widespread and indiscriminate use of antibiotics to treat bacterial infection has prompted evolution of several evading mechanisms from the ...
Amino Acid Sequence beta-Lactamases Anti-Infective Agents Support Vector Machine beta-Lactams Protein Structure, Secondary Sequence Analysis, Protein
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Decoding virulence and resistance in Klebsiella pneumoniae: Pharmacological insights, immunological dynamics, and in silico therapeutic strategies.

Microbial pathogenesis Aug 1, 2025
Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the leading members of ESKAPE pathogens, it plays a major role in a wide range of infections that cause ...
Klebsiella pneumoniae Klebsiella Infections Drug Discovery Drug Resistance, Multiple, Bacterial Humans Anti-Bacterial Agents beta-Lactamases Drug Resistance, Bacterial Bacterial Vaccines Virulence Factors Computer Simulation Immune Evasion Virulence
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DeepBL: a deep learning-based approach for in silico discovery of beta-lactamases.

Briefings in bioinformatics Jul 20, 2021
Beta-lactamases (BLs) are enzymes localized in the periplasmic space of bacterial pathogens, where they confer resistance to beta-lactam antibiotics. Experimental identification of BLs is costly yet crucial to understand beta-lactam resistance mechan...
Software Deep Learning Databases, Protein beta-Lactamases Computational Biology Proteome
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Single and joint antibacterial activity of aqueous garlic extract and Manuka honey on extended-spectrum beta-lactamase-producing Escherichia coli.

Transactions of the Royal Society of Tropical Medicine and Hygiene Oct 1, 2017
BACKGROUND: Multidrug resistance and recent technological advances have renewed interest in natural product drug discovery from ancient remedies such as Allium sativum (garlic) and honey. This study assessed antibacterial activity of aqueous garlic e...
Apitherapy Garlic Escherichia coli Plant Preparations Microbial Sensitivity Tests Escherichia coli Infections beta-Lactamases Phytotherapy Drug Resistance, Multiple, Bacterial Humans Honey Anti-Bacterial Agents
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