AI Medical Compendium Topic

Explore the latest research on artificial intelligence and machine learning in medicine.

Binding Sites

Showing 201 to 210 of 467 articles

Clear Filters

An Integrative Framework for Combining Sequence and Epigenomic Data to Predict Transcription Factor Binding Sites Using Deep Learning.

IEEE/ACM transactions on computational biology and bioinformatics Feb 3, 2021
Knowing the transcription factor binding sites (TFBSs) is essential for modeling the underlying binding mechanisms and follow-up cellular functions. Convolutional neural networks (CNNs) have outperformed methods in predicting TFBSs from the primary D...
Deep Learning Protein Binding Binding Sites Histone Code Computational Biology Chromatin Immunoprecipitation Sequencing Epigenesis, Genetic Transcription Factors
View on PubMed DOI

Robust principal component analysis-based prediction of protein-protein interaction hot spots.

Proteins Feb 2, 2021
Proteins often exert their function by binding to other cellular partners. The hot spots are key residues for protein-protein binding. Their identification may shed light on the impact of disease associated mutations on protein complexes and help des...
Protein Binding Computational Biology Proteins Humans Machine Learning ROC Curve Binding Sites Protein Interaction Mapping Protein Interaction Domains and Motifs Databases, Protein Principal Component Analysis Models, Molecular
View on PubMed DOI

DeepGRN: prediction of transcription factor binding site across cell-types using attention-based deep neural networks.

BMC bioinformatics Feb 1, 2021
BACKGROUND: Due to the complexity of the biological systems, the prediction of the potential DNA binding sites for transcription factors remains a difficult problem in computational biology. Genomic DNA sequences and experimental results from paralle...
Neural Networks, Computer Protein Binding Computational Biology Transcription Factors Binding Sites Chromatin
View on PubMed DOI

SSnet: A Deep Learning Approach for Protein-Ligand Interaction Prediction.

International journal of molecular sciences Jan 30, 2021
Computational prediction of Protein-Ligand Interaction (PLI) is an important step in the modern drug discovery pipeline as it mitigates the cost, time, and resources required to screen novel therapeutics. Deep Neural Networks (DNN) have recently show...
Binding Sites Caenorhabditis elegans Protein Structure, Secondary Protein Domains Ligands Drug Discovery Datasets as Topic Humans Deep Learning Animals Protein Binding
View on PubMed DOI

Systematic analysis of binding of transcription factors to noncoding variants.

Nature Jan 27, 2021
Many sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human trans...
Humans SELEX Aptamer Technique Protein Binding Polymorphism, Single Nucleotide Genome, Human Transcription Factors Disease Support Vector Machine Binding Sites Ligands
View on PubMed DOI

Classification and prediction of protein-protein interaction interface using machine learning algorithm.

Scientific reports Jan 19, 2021
Structural insight of the protein-protein interaction (PPI) interface can provide knowledge about the kinetics, thermodynamics and molecular functions of the complex while elucidating its role in diseases and further enabling it as a potential therap...
Thermodynamics Protein Interaction Mapping Databases, Protein Models, Molecular Binding Sites Molecular Docking Simulation Protein Interaction Maps Protein Binding Support Vector Machine Proteins
View on PubMed DOI

TargetDBP+: Enhancing the Performance of Identifying DNA-Binding Proteins via Weighted Convolutional Features.

Journal of chemical information and modeling Jan 7, 2021
Protein-DNA interactions exist ubiquitously and play important roles in the life cycles of living cells. The accurate identification of DNA-binding proteins (DBPs) is one of the key steps to understand the mechanisms of protein-DNA interactions. Alth...
Algorithms Support Vector Machine Position-Specific Scoring Matrices Databases, Protein DNA-Binding Proteins Binding Sites
View on PubMed DOI

An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding.

Genome biology Jan 7, 2021
BACKGROUND: Transcription factor (TF) binding specificity is determined via a complex interplay between the transcription factor's DNA binding preference and cell type-specific chromatin environments. The chromatin features that correlate with transc...
Chromatin Histones Binding Sites Genome Neural Networks, Computer Protein Binding Transcription Factors Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Gene Expression Regulation Humans
View on PubMed DOI

Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.

Chemical biology & drug design Dec 22, 2020
The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molec...
Drug Repositioning Humans SARS-CoV-2 Machine Learning Structure-Activity Relationship Viral Matrix Proteins COVID-19 Binding Sites Molecular Docking Simulation COVID-19 Drug Treatment Spike Glycoprotein, Coronavirus Antiviral Agents Protease Inhibitors Cell Line Deoxyadenosines Cell Survival
View on PubMed DOI

Deep neural networks for inferring binding sites of RNA-binding proteins by using distributed representations of RNA primary sequence and secondary structure.

BMC genomics Dec 17, 2020
BACKGROUND: RNA binding proteins (RBPs) play a vital role in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport, and modulation of mRNA translation and decay. The identification of RBP binding sites is a cru...
Neural Networks, Computer RNA-Binding Proteins Protein Binding RNA Binding Sites
View on PubMed DOI
Popular Topics
Recent Journals