AIMC Topic: Transferases (Other Substituted Phosphate Groups)

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CRLS1 influences liver metastasis in colon cancer by regulating lipid metabolism pathways.

Functional & integrative genomics Oct 21, 2025
Colon cancer is one of the leading causes of cancer-related mortality, with liver metastasis commonly complicating its progression and significantly worsening patient prognosis. This study aims to explore the relationship between liver metastasis in ...
Signal Transduction Cell Movement Gene Expression Regulation, Neoplastic Cell Proliferation Colonic Neoplasms Transferases (Other Substituted Phosphate Groups) Lipid Metabolism Male TOR Serine-Threonine Kinases Liver Neoplasms Cell Line, Tumor Humans Gene Regulatory Networks
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Using Steady-State Kinetics to Quantitate Substrate Selectivity and Specificity: A Case Study with Two Human Transaminases.

Molecules (Basel, Switzerland) Feb 18, 2022
We examined the ability of two human cytosolic transaminases, aspartate aminotransferase (GOT1) and alanine aminotransferase (GPT), to transform their preferred substrates whilst discriminating against similar metabolites. This offers an opportunity ...
Substrate Specificity Transferases (Other Substituted Phosphate Groups) Transaminases Alkyl and Aryl Transferases Enzyme Activation Binding Sites Protein Conformation Structure-Activity Relationship Animals Models, Molecular Humans Cattle Amino Acids Kinetics
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Discovering de novo peptide substrates for enzymes using machine learning.

Nature communications Dec 7, 2018
The discovery of peptide substrates for enzymes with exclusive, selective activities is a central goal in chemical biology. In this paper, we develop a hybrid computational and biochemical method to rapidly optimize peptides for specific, orthogonal ...
Peptides Protein Binding Machine Learning Bacterial Proteins Amino Acid Sequence Recombinant Proteins Bayes Theorem Transferases (Other Substituted Phosphate Groups) Substrate Specificity
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Variants in GNPTAB, GNPTG and NAGPA genes are associated with stutterers.

Gene Dec 28, 2017
Non-syndromic stuttering is a neurodevelopmental disorder characterized by disruptions in normal flow of speech in the form of repetition, prolongation and involuntary halts. Previously, mutations with more severe effects on GNPTAB and GNPTG have bee...
Transferases (Other Substituted Phosphate Groups) Heterozygote Male Homozygote Phenotype Humans Child, Preschool Child Phosphoric Diester Hydrolases Mutation Introns Female Genetic Predisposition to Disease Stuttering Mucolipidoses
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[Bridge between Total Synthesis of Bioactive Natural Products and Development of Drug Leads].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Jan 1, 2022
Although natural products are rich sources for drug discovery, only a small percentage of natural products themselves have been approved for clinical use, thus it is necessary to modulate various properties, such as efficacy, toxicity, and metabolic ...
Bacterial Proteins Transferases (Other Substituted Phosphate Groups) Transferases Tunicamycin Humans Biological Products
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