AIMC Topic: Camptothecin

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Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters.

Journal of pharmacological sciences May 4, 2019
Irinotecan (CPT-11) is a drug used against a wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension of the cycle, with the consequent impact on the prognosis of survival. The main goal of this work is to ...
Humans Machine Learning Forecasting Female Aged Colorectal Neoplasms Male Middle Aged Diarrhea Antineoplastic Combined Chemotherapy Protocols Oxaliplatin Models, Biological Fluorouracil Leukopenia Camptothecin Topoisomerase I Inhibitors Irinotecan Leucovorin Glucuronates Neutropenia
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Deep Fish.

SLAS discovery : advancing life sciences R & D Sep 26, 2016
Zebrafish ( Danio rerio) is an important vertebrate model organism in biomedical research, especially suitable for morphological screening due to its transparent body during early development. Deep learning has emerged as a dominant paradigm for data...
Neural Networks, Computer Animals Deep Learning Zebrafish Camptothecin
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Machine learning models for predicting chemotherapy-induced adverse drug reactions in colorectal cancer patients.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Sep 1, 2025
BACKGROUND: Chemotherapy-induced adverse drug reactions (ADRs) are common in patients with colorectal cancer. We developed four machine learning models to predict chemotherapy-induced ADRs and assessed the performance. These models leverage high-dime...
Humans Machine Learning Female Aged Colorectal Neoplasms Male Middle Aged Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Support Vector Machine Fluorouracil Drug-Related Side Effects and Adverse Reactions Capecitabine Organoplatinum Compounds Camptothecin Leucovorin
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