AIMC Topic: Neutropenia

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Machine learning-based prediction reveals kinase MAP4K4 regulates neutrophil differentiation through phosphorylating apoptosis-related proteins.

PLoS computational biology Mar 17, 2025
Neutrophils, an essential innate immune cell type with a short lifespan, rely on continuous replenishment from bone marrow (BM) precursors. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the ...
Machine Learning Animals Mice Humans Phosphorylation Cell Differentiation Mice, Knockout Intracellular Signaling Peptides and Proteins Hematopoietic Stem Cells Neutropenia Apoptosis Mice, Inbred C57BL Protein Serine-Threonine Kinases Computational Biology Neutrophils
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AI Enhanced explainable early prediction of blood culture positivity in neutropenic patients using clinical and hematologic parameters.

Computers in biology and medicine Mar 15, 2025
Leukemia patients who receive chemotherapy experience a decline in neutrophils and an increased risk of infections. Neutropenic sepsis is a life-threatening condition and a major cause of cancer-related mortality. Patients with neutropenic sepsis are...
Female Aged Adult Humans Machine Learning Bacteremia Blood Culture Neutropenia Male Middle Aged Sepsis
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Deep-learning-based personalized prediction of absolute neutrophil count recovery and comparison with clinicians for validation.

Journal of biomedical informatics Dec 10, 2022
Neutropenia and its complications are major adverse effects of cytotoxic chemotherapy. The time to recovery from neutropenia varies from patient to patient, and cannot be easily predicted even by experts. Therefore, we trained a deep learning model u...
Neoplasms Deep Learning Child Humans Neutrophils Neutropenia
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Development and utility assessment of a machine learning bloodstream infection classifier in pediatric patients receiving cancer treatments.

BMC cancer Nov 13, 2020
BACKGROUND: Objectives were to build a machine learning algorithm to identify bloodstream infection (BSI) among pediatric patients with cancer and hematopoietic stem cell transplantation (HSCT) recipients, and to compare this approach with presence o...
Male Neoplasms Infant Sepsis Adolescent Retrospective Studies Female Infant, Newborn Machine Learning Prognosis Hematopoietic Stem Cell Transplantation Neutropenia Bacteremia Support Vector Machine Follow-Up Studies Child, Preschool Child Humans
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Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters.

Journal of pharmacological sciences May 4, 2019
Irinotecan (CPT-11) is a drug used against a wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension of the cycle, with the consequent impact on the prognosis of survival. The main goal of this work is to ...
Fluorouracil Leukopenia Camptothecin Oxaliplatin Models, Biological Glucuronates Neutropenia Topoisomerase I Inhibitors Irinotecan Leucovorin Colorectal Neoplasms Male Middle Aged Diarrhea Antineoplastic Combined Chemotherapy Protocols Forecasting Female Aged Humans Machine Learning
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Diagnosis of coronavirus disease 2019 and the potential role of deep learning: insights from the experience of Cairo University Hospitals.

The Journal of international medical research Jul 1, 2022
OBJECTIVES: Early detection of coronavirus disease 2019 (COVID-19) is crucial for patients and public health to ensure pandemic control. We aimed to correlate clinical and laboratory data of patients with COVID-19 and their polymerase chain reaction ...
Anosmia SARS-CoV-2 Deep Learning Ferritins Hospitals, University Neutropenia Humans COVID-19 Retrospective Studies
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Prediction of Neutropenic Events in Chemotherapy Patients: A Machine Learning Approach.

JCO clinical cancer informatics Aug 1, 2021
PURPOSE: Severe and febrile neutropenia present serious hazards to patients with cancer undergoing chemotherapy. We seek to develop a machine learning-based neutropenia prediction model that can be used to assess risk at the initiation of a chemother...
Risk Factors Neutropenia Humans Machine Learning Algorithms Electronic Health Records
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