AIMC Topic: Capecitabine

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Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

mBio May 20, 2025
Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced by anticancer drugs, data from patients paired with careful side effect monitoring remains limited....
Colorectal Neoplasms Male Middle Aged Antineoplastic Agents Humans Female Vitamins Vitamin K 2 Metagenomics Capecitabine Feces Bacteria Gastrointestinal Microbiome Escherichia coli
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Noncirrhotic Portal Hypertension after Trastuzumab Emtansine in HER2-positive Breast Cancer as Determined by Deep Learning-measured Spleen Volume at CT.

Radiology Aug 9, 2022
Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for use in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Case reports have suggested an association between T-DM1 and portal hypertension. Purpo...
Humans Retrospective Studies Tomography, X-Ray Computed Female Antineoplastic Combined Chemotherapy Protocols Capecitabine Receptor, ErbB-2 Spleen Breast Neoplasms Middle Aged Deep Learning Ado-Trastuzumab Emtansine Lapatinib Hypertension, Portal Splenomegaly
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Using Machine Learning Approaches to Predict Short-Term Risk of Cardiotoxicity Among Patients with Colorectal Cancer After Starting Fluoropyrimidine-Based Chemotherapy.

Cardiovascular toxicology Nov 18, 2021
Cardiotoxicity is a severe side effect for colorectal cancer (CRC) patients undergoing fluoropyrimidine-based chemotherapy. To develop and compare machine learning algorithms to predict cardiotoxicity risk among nationally representative CRC patients...
Capecitabine Antimetabolites, Antineoplastic Cardiotoxicity Risk Assessment Time Factors Treatment Outcome Predictive Value of Tests Fluorouracil SEER Program Heart Diseases Aged Humans Colorectal Neoplasms Decision Support Techniques Machine Learning Male Female Middle Aged Risk Factors
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Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 30, 2018
Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug...
Alkanesulfonates Drug Contamination Reproducibility of Results Limit of Detection Solvents Tandem Mass Spectrometry Capecitabine Gas Chromatography-Mass Spectrometry Imatinib Mesylate Solubility Mutagens
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[Not Available].

Recenti progressi in medicina Nov 1, 2024
This study explores the potential use of ChatGPT, an AI-based language model, in assessing herbal-drug interactions (HDi) to enhance clinical decision-making. HDi can pose significant health risks by reducing drug efficacy or causing unwanted side ef...
Professional Role Adenocarcinoma Dietary Supplements Rectal Neoplasms Capecitabine Plant Preparations Humans Herb-Drug Interactions Artificial Intelligence Pharmacists Clinical Decision-Making
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[Stage Ⅳ Breast Cancer with Difficulty in Initiating Chemotherapy-A Case Report].

Gan to kagaku ryoho. Cancer & chemotherapy Dec 1, 2019
We report a case of breast cancer(T4b[skin], N1, M1[lung], ER-, PR-, HER2 3+)in a 63-year-old woman with liver dysfunction of unknown cause(T-Bil 3.6mg/dL, ALP 3,483 U/L, AST 214 U/L, ALT 320 U/L, g / -GTP 1,943 U/L). Further- more, serum CA19-9(4,67...
Middle Aged Capecitabine Humans Antineoplastic Combined Chemotherapy Protocols Receptor, ErbB-2 Neoplasm Staging Female Trastuzumab Mastectomy Breast Neoplasms
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[A Case of Two Curative Resections for the Peritoneal Dissemination of Transverse Colon Cancer].

Gan to kagaku ryoho. Cancer & chemotherapy Dec 1, 2019
No large clinical trials have been conducted to prove the efficacy of peritoneal dissemination resection for colorectal cancer, and no evidence has shown the usefulness of resection for metachronous peritoneal dissemination. An elderly woman in her 7...
Peritoneal Neoplasms Capecitabine Neoplasm Recurrence, Local Colon, Transverse Colonic Neoplasms Humans Female Aged Antineoplastic Combined Chemotherapy Protocols
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[A Patient with Rectal Cancer and Multiple Lung Metastases Treated with XELOX plus Bevacizumab (Bev) Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy Nov 1, 2015
The patient was a 76-year-old woman who underwent laparoscopic-assisted low anterior resection for rectal cancer. According to the Japanese classification of colorectal carcinoma (8th Edition), the tumor was tub1, ly0, v0, and pStage Ⅰ (pT1bN0M0), Cu...
Treatment Outcome Fluorouracil Rectal Neoplasms Capecitabine Colectomy Deoxycytidine Bevacizumab Female Aged Lung Neoplasms Antineoplastic Combined Chemotherapy Protocols Humans Oxaloacetates
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[A Case of Gastric Cancer with Multiple Liver Metastases Treated with XP Chemotherapy and RFA Resulting in a Complete Response for a Long Time].

Gan to kagaku ryoho. Cancer & chemotherapy Nov 1, 2015
A 60-year-old man underwent total gastrectomy with Japanese D2 lymph node dissection for advanced gastric cancer. The resected specimen was diagnosed as well-differentiated tubular carcinoma, pT3, pN1, cM0, and the final stage was considered as ⅡB. D...
Antineoplastic Combined Chemotherapy Protocols Gastrectomy Male Catheter Ablation Cisplatin Humans Middle Aged Capecitabine Remission Induction Stomach Neoplasms Time Factors Liver Neoplasms
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