The role of intrinsically disordered protein regions (IDRs) in cellular processes has become increasingly evident over the last years. These IDRs continue to challenge structural biology experiments because they lack a well-defined conformation, and ...
Journal of bioinformatics and computational biology
Apr 21, 2022
RNA-binding proteins (RBPs) have crucial roles in various cellular processes such as alternative splicing and gene regulation. Therefore, the analysis and identification of RBPs is an essential issue. However, although many computational methods have...
Interdisciplinary sciences, computational life sciences
Apr 15, 2022
MOTIVATION: Exploring the interrelationships between microbes and disease can help microbiologists make decisions and plan treatments. Predicting new microbe-disease associations currently relies on biological experiments and domain knowledge, which ...
Model selection is an important issue in support vector machine-based recursive feature elimination (SVM-RFE). However, performing model selection on a linear SVM-RFE is difficult because the generalization error of SVM-RFE is hard to estimate. This ...
IEEE journal of biomedical and health informatics
Apr 14, 2022
Deciphering the relationship between transcription factors (TFs) and DNA sequences is very helpful for computational inference of gene regulation and a comprehensive understanding of gene regulation mechanisms. Transcription factor binding sites (TFB...
BACKGROUND: In research on new drug discovery, the traditional wet experiment has a long period. Predicting drug-target interaction (DTI) in silico can greatly narrow the scope of search of candidate medications. Excellent algorithm model may be more...
OBJECTIVES: Immune microenvironment was closely related to the occurrence and progression of colorectal cancer (CRC). The objective of the current research was to develop and verify a Machine learning survival predictive system for CRC based on immun...
Deep Learning (DL) has recently enabled unprecedented advances in one of the grand challenges in computational biology: the half-century-old problem of protein structure prediction. In this paper we discuss recent advances, limitations, and future pe...
International journal of molecular sciences
Mar 31, 2022
Identifying new disease indications for existing drugs can help facilitate drug development and reduce development cost. The previous drug-disease association prediction methods focused on data about drugs and diseases from multiple sources. However,...
Accurate identification of DNA-binding proteins (DBPs) is critical for both understanding protein function and drug design. DBPs also play essential roles in different kinds of biological activities such as DNA replication, repair, transcription, and...
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