In longitudinal observational studies with time-varying confounders, the generalized computation algorithm formula (g-formula) is a principled tool to estimate the average causal effect of a treatment regimen. However, the standard non-iterative g-fo...
Modeling with multiomics data presents multiple challenges, such as the high dimensionality of the problem ( ), the presence of interactions between features, and the need for integration between multiple data sources. We establish an interaction mo...
PURPOSE: The surge of treatments for COVID-19 in the second quarter of 2020 had a low prevalence of treatment and high outcome risk. Motivated by that, we conducted a simulation study comparing disease risk scores (DRS) and propensity scores (PS) usi...
The blood-brain barrier (BBB) functions as a vital protective mechanism, restricting the entry of substances and xenobiotics into the central nervous system (CNS). Consequently, BBB penetration is a critical aspect of absorption, distribution, metabo...
Medical Visual Question Answering (Med-VQA) aims to furnish precise responses to clinical queries related to medical imagery. While its transformative potential in healthcare is undeniable, current solutions remain nascent and are yet to see widespre...
Computer methods and programs in biomedicine
Jun 1, 2025
BACKGROUND AND OBJECTIVES: Electrophysiological source imaging (ESI) is a challenging technique for noninvasively measuring brain activity, which involves solving a highly ill-posed inverse problem. Traditional methods attempt to address this challen...
BACKGROUND: Managing blood glucose levels in Type 1 Diabetes Mellitus (T1DM) is essential to prevent complications. Traditional insulin delivery methods often require significant patient involvement, limiting automation. Reinforcement Learning (RL)-b...
Computer methods and programs in biomedicine
Jun 1, 2025
OBJECTIVE: Early fluid resuscitation is crucial in the treatment of sepsis, yet the optimal dosage remains debated. This study aims to determine the optimal multi-stage fluid resuscitation dosage for sepsis patients.
IEEE transactions on neural networks and learning systems
Jun 1, 2025
The brain is able to acquire and store memories of everyday experiences in real-time. It can also selectively forget information to facilitate memory updating. However, our understanding of the underlying mechanisms and coordination of these processe...
IEEE transactions on neural networks and learning systems
Jun 1, 2025
Spiking neural networks (SNNs) are biologically plausible models known for their computational efficiency. A significant advantage of SNNs lies in the binary information transmission through spike trains, eliminating the need for multiplication opera...
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