Briefings in bioinformatics
Nov 19, 2022
Time-course single-cell RNA sequencing (scRNA-seq) data have been widely used to explore dynamic changes in gene expression of transcription factors (TFs) and their target genes. This information is useful to reconstruct cell-type-specific gene regul...
Briefings in bioinformatics
Nov 19, 2022
Emerging evidence indicates that circular RNAs (circRNAs) can provide new insights and potential therapeutic targets for disease diagnosis and treatment. However, traditional biological experiments are expensive and time-consuming. Recently, deep lea...
Briefings in bioinformatics
Nov 19, 2022
Drug repositioning (DR) is a promising strategy to discover new indicators of approved drugs with artificial intelligence techniques, thus improving traditional drug discovery and development. However, most of DR computational methods fall short of t...
Briefings in bioinformatics
Nov 19, 2022
The rapid development of biomedicine has produced a large number of biomedical written materials. These unstructured text data create serious challenges for biomedical researchers to find information. Biomedical named entity recognition (BioNER) and ...
Briefings in bioinformatics
Nov 19, 2022
Accurate prediction of molecular properties, such as physicochemical and bioactive properties, as well as ADME/T (absorption, distribution, metabolism, excretion and toxicity) properties, remains a fundamental challenge for molecular design, especial...
Bioinformatics (Oxford, England)
Nov 15, 2022
MOTIVATION: Tumor mutational burden (TMB) is an indicator of the efficacy and prognosis of immune checkpoint therapy in colorectal cancer (CRC). In general, patients with higher TMB values are more likely to benefit from immunotherapy. Though whole-e...
Journal of the American Medical Informatics Association : JAMIA
Nov 14, 2022
OBJECTIVE: Alzheimer's disease (AD) is the most common neurodegenerative disorder with one of the most complex pathogeneses, making effective and clinically actionable decision support difficult. The objective of this study was to develop a novel mul...
Nucleic acids research
Nov 11, 2022
Massively parallel reporter assay (MPRA) is a high-throughput method that enables the study of the regulatory activities of tens of thousands of DNA oligonucleotides in a single experiment. While MPRA experiments have grown in popularity, their small...
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Nov 9, 2022
In recent years, the application of artificial intelligence technology in the field of orthodontics has gradually increased, and deep learning, as a hot direction, has also been rapidly applied in the detection, evaluation, diagnosis, prediction and ...
World journal of gastroenterology
Nov 7, 2022
BACKGROUND: Endoscopy artifacts are widespread in real capsule endoscopy (CE) images but not in high-quality standard datasets.