IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
N-methylguanosine (m7G), one of the mainstream post-transcriptional RNA modifications, occupies an exceedingly significant place in medical treatments. However, classic approaches for identifying m7G sites are costly both in time and equipment. Meanw...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Retrosynthesis prediction is a fundamental problem in organic chemistry and drug synthesis. We proposed an end-to-end deep learning model called CTsynther (Contrastive Transformer for single-step retrosynthesis prediction model) that could provide si...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Relation extraction, a crucial task in understanding the intricate relationships between entities in biomedical domains, has predominantly focused on binary relations within single sentences. However, in practical biomedical scenarios, relationships ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
The prediction of drug-target affinity (DTA) plays a crucial role in drug development and the identification of potential drug targets. In recent years, computer-assisted DTA prediction has emerged as a significant approach in this field. In this stu...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
The function labeling of enzymes has a wide range of application value in the medical field, industrial biology and other fields. Scientists define enzyme categories by enzyme commission (EC) numbers. At present, although there are some tools for enz...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Biomedical Coreference Resolution focuses on identifying the coreferences in biomedical texts, which normally consists of two parts: (i) mention detection to identify textual representation of biological entities and (ii) finding their coreference li...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Understanding the intricate regulatory relationships among genes is crucial for comprehending the development, differentiation, and cellular response in living systems. Consequently, inferring gene regulatory networks (GRNs) based on observed data ha...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Due to the broad-spectrum and high-efficiency antibacterial activity, antimicrobial peptides (AMPs) and their functions have been studied in the field of drug discovery. Using biological experiments to detect the AMPs and corresponding activities req...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
The virus poses a longstanding and enduring danger to various forms of life. Despite the ongoing endeavors to combat viral diseases, there exists a necessity to explore and develop novel therapeutic options. Antiviral peptides are bioactive molecules...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Deep learning approaches, such as convolution neural networks (CNNs) and deep recurrent neural networks (RNNs), have been the backbone for predicting protein function, with promising state-of-the-art (SOTA) results. RNNs with an in-built ability (i) ...