AIMC Topic: Drug Compounding

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Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach.

International journal of pharmaceutics Oct 26, 2022
3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), usin...
Excipients Drug Compounding Tablets Lasers Powders Expert Systems
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Evaluation of a Self-Supervised Machine Learning Method for Screening of Particulate Samples: A Case Study in Liquid Formulations.

Journal of pharmaceutical sciences Oct 12, 2022
Imaging is commonly used as a characterization method in the pharmaceuticals industry, including for quantifying subvisible particles in solid and liquid formulations. Extracting information beyond particle size, such as classifying morphological sub...
Neural Networks, Computer Supervised Machine Learning Drug Compounding Image Processing, Computer-Assisted Proteins
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Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions.

AAPS PharmSciTech Sep 2, 2022
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-soluble drugs. The escalating number of drugs with poor aqueous solubility, poor dissolution, and poor oral bioavailability is an unresolved problem that requires...
Water Solubility Artificial Intelligence Excipients Drug Compounding Chemistry, Pharmaceutical Biological Availability
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Contribution of an anticancer drug compounding robot in reducing the risks of manual preparation in a hospital pharmacy unit specialized in oncology.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners Aug 8, 2022
INTRODUCTION: In the last few years, pharmaceutical technology has evolved. In the field of oncology pharmacy, robots for the preparation of anti-cancer drugs have appeared to progressively replace manual preparation. The objective of this study is t...
Pharmacy Service, Hospital Pharmacy Robotics Drug Compounding Antineoplastic Agents Humans
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Risk Assessment for a Twin-Screw Granulation Process Using a Supervised Physics-Constrained Auto-encoder and Support Vector Machine Framework.

Pharmaceutical research Aug 4, 2022
Quality risk management is an important task when it pertains to the pharmaceutical industry, as this is directly related to product performance. With the ICH Q9 guidelines, several regulatory bodies have encouraged the pharmaceutical industry to imp...
Drug Compounding Technology, Pharmaceutical Particle Size Physics Risk Assessment Support Vector Machine
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Machine Learning Analysis Provides Insight into Mechanisms of Protein Particle Formation Inside Containers During Mechanical Agitation.

Journal of pharmaceutical sciences Jul 11, 2022
Container choice can influence particle generation within protein formulations. Incompatibility between proteins and containers can manifest as increased particle concentrations, shifts in particle size distributions and changes in particle morpholog...
Particle Size Drug Compounding Machine Learning Antibodies, Monoclonal
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Real-time coating thickness measurement and defect recognition of film coated tablets with machine vision and deep learning.

International journal of pharmaceutics Jun 24, 2022
This paper presents a system, where images acquired with a digital camera are coupled with image analysis and deep learning to identify and categorize film coating defects and to measure the film coating thickness of tablets. There were 5 different c...
Deep Learning Tablets Quality Control Drug Compounding Chemistry, Pharmaceutical Technology, Pharmaceutical
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Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets.

AAPS PharmSciTech May 9, 2022
Sediment delivery model (SeDeM) system is innovative tool to correlate micromeritic properties of powders with compressibility. It involves computation of indices which facilitate direct compressibility of solids and enable corrective measures throug...
Drug Compounding Solubility Excipients Powders Expert Systems Tablets
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Automated preparation of cytotoxic drugs: the evidence for an interface between the robot and computerized provider order entry?

European journal of hospital pharmacy : science and practice Mar 10, 2022
Drug Compounding Medication Errors Robotics Medical Order Entry Systems Humans Antineoplastic Agents
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A Strategy for the Effective Optimization of Pharmaceutical Formulations Based on Parameter-Optimized Support Vector Machine Model.

AAPS PharmSciTech Jan 31, 2022
Engineering pharmaceutical formulations is governed by a number of variables, and the finding of the optimal preparation is intricately linked to the exploration of a multiparametric space through a variety of optimization tasks. As a result, making ...
Least-Squares Analysis Reproducibility of Results Drug Compounding Support Vector Machine Neural Networks, Computer
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