AIMC Topic: Drug Compounding
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Qualification of a chemotherapy-compounding robot.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Apr 18, 2019
KIRO® Oncology (Kiro Grifols, Spain) is a robotic system for automated compounding of sterile injectable drugs including intravenous cytotoxic treatments. The present article describes the qualification procedure applied prior to production phases. P...
Deep Learning and Random Forest Approach for Finding the Optimal Traditional Chinese Medicine Formula for Treatment of Alzheimer's Disease.
Journal of chemical information and modeling
Apr 2, 2019
It has demonstrated that glycogen synthase kinase 3β (GSK3β) is related to Alzheimer's disease (AD). On the basis of the world largest traditional Chinese medicine (TCM) database, a network-pharmacology-based approach was utilized to investigate TCM ...
Computational Biology
Support Vector Machine
Medicine, Chinese Traditional
Molecular Docking Simulation
Deep Learning
Protein Interaction Maps
Quantitative Structure-Activity Relationship
Protein Conformation
Databases, Pharmaceutical
Glycogen Synthase Kinase 3
Molecular Dynamics Simulation
Alzheimer Disease
Drug Compounding
Application of the SeDeM Expert System in Studies for Direct Compression Suitability on Mixture of Rhodiola Extract and an Excipient.
AAPS PharmSciTech
Feb 11, 2019
The SeDeM expert system is used to reveal direct compression (DC) suitability of the active ingredients and excipients in preformulation. In this study, the system was used to predict compressibility of rhodiola extract (RhE) and its mixture with exc...
Microbiological validation of a robot for the sterile compounding of injectable non-hazardous medications in a hospital environment.
European journal of hospital pharmacy : science and practice
Feb 4, 2019
OBJECTIVES: To design and execute a comprehensive microbiological validation protocol to assess a brand-new sterile compounding robot in a hospital pharmacy environment, according to ISO and EU GMP standards.
Microbiological performance of a robotic system for aseptic compounding of cytostatic drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jan 31, 2019
BACKGROUND: Compounding of cytostatic drugs requires strict aseptic procedures, while exposure to toxic drugs and repetitive manual movements should be minimized. Furthermore, reuse of vials is desirable to lower the costs. To assess if all this migh...
Simulation program of a cytotoxic compounding robot for monoclonal antibodies and anti-infectious sterile drug preparation.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Jan 16, 2019
The aim of this study was to develop a specific simulation program for the validation of a cytotoxic compounding robot, KIRO® Oncology, for the preparation of sterile monoclonal antibodies and anti-infectious drugs. The impact of excipient formulatio...
The application of machine learning algorithms in understanding the effect of core/shell technique on improving powder compactability.
International journal of pharmaceutics
Nov 20, 2018
This study systemically investigated the application of core/shell technique to improve powder compactability. A 28-run Design-of-Experiment (DoE) was conducted to evaluate the effects of the type of core and shell materials and their concentrations ...
Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations.
Journal of pharmaceutical sciences
Oct 27, 2018
Current technologies for monitoring the subvisible particles that may be generated during fill-finish operations for protein formulations are cumbersome. Measurement times are generally too long for real-time analysis, and the high protein concentrat...
Neurotoxicity of intraneural injection of bupivacaine liposome injectable suspension versus bupivacaine hydrochloride in a porcine model.
Veterinary anaesthesia and analgesia
Oct 11, 2018
OBJECTIVE: To test whether neurotoxic effects of a bupivacaine liposome injectable suspension differ from those of a standard formulation of bupivacaine hydrochloride (HCl) after intraneural injection into the sciatic nerves in pigs.
Comparison of multi-linear regression, particle swarm optimization artificial neural networks and genetic programming in the development of mini-tablets.
International journal of pharmaceutics
Sep 15, 2018
In the present study, the preparation of pharmaceutical mini-tablets was attempted in the framework of Quality by Design (QbD) context, by comparing traditionally used multi-linear regression (MLR), with artificially-intelligence based regression tec...
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