AIMC Topic: Drug Delivery Systems

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Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks.

PLoS computational biology Sep 5, 2023
Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using multi-targeted drugs, we developed a machine learning pipeline to unravel the target landscape of ...
Neural Networks, Computer Workflow Drug Delivery Systems Protein Kinase Inhibitors Machine Learning
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Robotic self-modulation enhances implantable long-acting drug delivery devices.

Science robotics Aug 30, 2023
Integrating fibrotic capsule sensing with soft robotics may boost long-term performance of implantable drug delivery devices.
Robotics Prostheses and Implants Drug Delivery Systems
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Soft robot-mediated autonomous adaptation to fibrotic capsule formation for improved drug delivery.

Science robotics Aug 30, 2023
The foreign body response impedes the function and longevity of implantable drug delivery devices. As a dense fibrotic capsule forms, integration of the device with the host tissue becomes compromised, ultimately resulting in device seclusion and tre...
Drug Delivery Systems Robotics Humans Methylene Blue Electric Impedance Foreign Bodies
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Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components.

Molecules (Basel, Switzerland) Aug 7, 2023
Diffusion is one of the key nature processes which plays an important role in respiration, digestion, and nutrient transport in cells. In this regard, the present article aims to review various diffusion approaches used to fabricate different functio...
Stimuli Responsive Polymers Drug Delivery Systems Hydrogels Electronics Robotics
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Microrobots for Biomedicine: Unsolved Challenges and Opportunities for Translation.

ACS nano Jul 26, 2023
Microrobots are being explored for biomedical applications, such as drug delivery, biological cargo transport, and minimally invasive surgery. However, current efforts largely focus on proof-of-concept studies with nontranslatable materials through a...
Drug Delivery Systems Humans Minimally Invasive Surgical Procedures Robotics Biocompatible Materials
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Knowledge Gaps in Generating Cell-Based Drug Delivery Systems and a Possible Meeting with Artificial Intelligence.

Molecular pharmaceutics Jul 10, 2023
Cell-based drug delivery systems are new strategies in targeted delivery in which cells or cell-membrane-derived systems are used as carriers and release their cargo in a controlled manner. Recently, great attention has been directed to cells as carr...
Nanomedicine Machine Learning Artificial Intelligence Nanotechnology Drug Delivery Systems
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Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery.

Journal of materials chemistry. B Jul 5, 2023
Microrobots for targeted drug delivery in blood vessels have attracted increasing interest from researchers. In this work, hydrogel-based capsule microrobots are used to wrap drugs and deliver drugs in blood vessels. In order to prepare capsule micro...
Robotics Magnetics Hydrogels Computer Simulation Drug Delivery Systems
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Role of nanotechnology in the prolonged release of drugs by the subcutaneous route.

Expert opinion on drug delivery Jun 12, 2023
INTRODUCTION: Subcutaneous physiology is distinct from other parenteral routes that benefit the administration of prolonged-release formulations. A prolonged-release effect is particularly convenient for treating chronic diseases because it is associ...
Nanotechnology Injections, Subcutaneous Pharmaceutical Preparations Drug Delivery Systems Artificial Intelligence
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Explainability and white box in drug discovery.

Chemical biology & drug design Apr 27, 2023
Recently, artificial intelligence (AI) techniques have been increasingly used to overcome the challenges in drug discovery. Although traditional AI techniques generally have high accuracy rates, there may be difficulties in explaining the decision pr...
Drug Delivery Systems Drug Discovery Machine Learning Artificial Intelligence Algorithms
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Bubble-Based Microrobots with Rapid Circular Motions for Epithelial Pinning and Drug Delivery.

Small (Weinheim an der Bergstrasse, Germany) Apr 14, 2023
Remotely powered microrobots are proposed as next-generation vehicles for drug delivery. However, most microrobots swim with linear trajectories and lack the capacity to robustly adhere to soft tissues. This limits their ability to navigate complex b...
Mice Drug Delivery Systems Microtechnology Robotics Epithelium Animals
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