AIMC Topic: Drug Delivery Systems

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BCM-DTI: A fragment-oriented method for drug-target interaction prediction using deep learning.

Computational biology and chemistry Mar 5, 2023
The identification of drug-target interaction (DTI) is significant in drug discovery and development, which is usually of high cost in time and money due to large amount of molecule and protein space. The application of deep learning in predicting DT...
Proteins Drug Development Drug Delivery Systems Deep Learning Drug Discovery
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Pathway of transient electronics towards connected biomedical applications.

Nanoscale Mar 2, 2023
Transient electronic devices have shown promising applications in hardware security and medical implants with diagnosing therapeutics capabilities since their inception. Control of the device transience allows the device to "dissolve at will" after i...
Artificial Intelligence Electronics Electric Power Supplies Prostheses and Implants Drug Delivery Systems
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Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review.

AAPS PharmSciTech Feb 9, 2023
There has been a tremendous increase in the investigations of three-dimensional (3D) printing for biomedical and pharmaceutical applications, and drug delivery in particular, ever since the US FDA approved the first 3D printed medicine, SPRITAM® (lev...
Pharmaceutical Preparations Printing, Three-Dimensional Technology, Pharmaceutical Artificial Intelligence Drug Delivery Systems Humans
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Biphasic burst and sustained transdermal delivery in vivo using an AI-optimized 3D-printed MN patch.

International journal of pharmaceutics Feb 6, 2023
The objective of the present study was to fabricate microneedles for delivering lipophilic active ingredients (APIs) using digital light processing (DLP) printing technology and quality by design (QbD) supplemented by artificial intelligence (AI) alg...
Drug Delivery Systems Animals Artificial Intelligence Skin Pharmaceutical Preparations Printing, Three-Dimensional Rats Humans Transdermal Patch Needles Ibuprofen Administration, Cutaneous
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Bioinspired microrobots: Opportunities and challenges in targeted cancer therapy.

Journal of controlled release : official journal of the Controlled Release Society Jan 19, 2023
Chemotherapy is still the most effective technique to treat many forms of cancer. However, it also carries a high risk of side effects. Numerous nanomedicines have been developed to avoid unintended consequences and significant negative effects of co...
Robotics Neoplasms Nanomedicine Drug Delivery Systems Humans Pharmaceutical Preparations
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Computational Biomaterials: Computational Simulations for Biomedicine.

Advanced materials (Deerfield Beach, Fla.) Dec 29, 2022
With the flourishing development of material simulation methods (quantum chemistry methods, molecular dynamics, Monte Carlo, phase field, etc.), extensive adoption of computing technologies (high-throughput, artificial intelligence, machine learning,...
Drug Delivery Systems Artificial Intelligence Biocompatible Materials Molecular Dynamics Simulation Biomimetics
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Microrobots for Targeted Delivery and Therapy in Digestive System.

ACS nano Dec 19, 2022
Untethered miniature robots enable targeted delivery and therapy deep inside the gastrointestinal tract in a minimally invasive manner. By combining actuation systems and imaging tools, significant progress has been made toward the development of fun...
Digestive System Robotics Drug Delivery Systems
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Technical and engineering considerations for designing therapeutics and delivery systems.

Journal of controlled release : official journal of the Controlled Release Society Dec 7, 2022
The newly-emerged pathological conditions and increased rates of drug resistance necessitate application of the state-of-the-art technologies for accelerated discovery of the therapeutic candidates and obtaining comprehensive knowledge about their ta...
Pharmaceutical Preparations Biological Availability Artificial Intelligence Drug Delivery Systems
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DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets.

Communications biology Nov 24, 2022
The druggability of targets is a crucial consideration in drug target selection. Here, we adopt a stochastic semi-supervised ML framework to develop DrugnomeAI, which estimates the druggability likelihood for every protein-coding gene in the human ex...
Software Humans Drug Delivery Systems Machine Learning
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Establishing the Controlled Delivery of VEGF Using a Hydrogel Loaded Soft Robotic Drug Delivery System With the Aim to Prevascularise Implant Site for Islet Transplantation: Erratum.

Transplantation Nov 22, 2022
Hydrogels Robotics Drug Delivery Systems Vascular Endothelial Growth Factor A Islets of Langerhans Transplantation
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