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Febuxostat

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Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 38345582
Hyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at...
Allopurinol Febuxostat Glomerular Filtration Rate Gout Suppressants Humans Hyperuricemia Renal Insufficiency, Chronic Treatment Outcome Uric Acid
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Development of LC-MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects.

Journal of clinical pharmacy and therapeutics 33201513
WHAT IS KNOWN AND OBJECTIVE: Febuxostat is a well-known drug for treating hyperuricemia and gout. The published methods for determination of febuxostat in human plasma might be unsuitable for high-throughput determination and widespread application. ...
Area Under Curve Chromatography, Liquid Drug Stability Febuxostat Gout Suppressants Half-Life Healthy Volunteers Humans Metabolic Clearance Rate Neural Networks, Computer Reproducibility of Results Tandem Mass Spectrometry
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A comprehensive study of pharmaceutics solubility in supercritical solvent through diverse thermodynamic and hybrid Machine learning approaches.

International journal of pharmaceutics 39137821
The pharmaceutical industry is increasingly drawn to the research of innovative drug delivery systems through the use of supercritical CO (scCO)-based techniques. Measuring the solubility of drugs in scCO at varying conditions is a crucial parameter ...
Carbon Dioxide Chemistry, Pharmaceutical Chlorpromazine Febuxostat Machine Learning Models, Chemical Solubility Solvents Thermodynamics
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