AI Medical Compendium Topic

Explore the latest research on artificial intelligence and machine learning in medicine.

Half-Life

Showing 1 to 10 of 19 articles

Clear Filters

Preformulation studies of thymopentin: analytical method development, physicochemical properties, kinetic degradation investigations and formulation perspective.

Drug development and industrial pharmacy 35234086
Thymopentin (TP5) is a synthetic pentapeptide with immunomodulatory properties. Given the previously described poor absorption of TP5, preformulation data is required to support effective formulation development. In this manuscript, an analytical met...
Drug Liberation Half-Life Kinetics Solubility Thymopentin
View on PubMed DOI

Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria 32310932
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} รจ un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Anhedonia Antipsychotic Agents Cognition Disorders Cytochrome P-450 CYP2D6 Inducers Cytochrome P-450 CYP3A Inducers Drug Interactions Drug Substitution Half-Life Humans Ketoconazole Piperazines Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Schizophrenia Time Factors
View on PubMed DOI

PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica 29624254
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Administration, Oral Anti-Inflammatory Agents, Non-Steroidal Area Under Curve Chromatography, High Pressure Liquid Cross-Over Studies Half-Life Healthy Volunteers Humans Male Metabolic Clearance Rate Models, Biological Pakistan Sulfonamides Tablets Therapeutic Equivalency Young Adult
View on PubMed

THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Acta poloniae pharmaceutica 29513963
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Acetaminophen Adult Aged Aged, 80 and over Analgesics, Non-Narcotic Antipyretics Area Under Curve Biological Availability Chromatography, High Pressure Liquid Drug Monitoring Female Half-Life Humans Infusions, Intravenous Kidney Kidney Neoplasms Male Metabolic Clearance Rate Middle Aged Models, Biological Nephrectomy Renal Elimination Spectrophotometry, Ultraviolet
View on PubMed

Pharmacokinetics of a Single Intramuscular Injection of Long-Acting Ceftiofur Crystalline-Free Acid in Cattle Egrets ( Bubulcus ibis).

Journal of avian medicine and surgery 29327960
We determined the pharmacokinetic properties of ceftiofur crystalline-free acid (CCFA), a long-acting antibiotic, after a single intramuscular injection in cattle egrets ( Bubulcus ibis). A dose of 20 mg/kg was administered intramuscularly to 18 bird...
Animals Anti-Bacterial Agents Area Under Curve Birds Cephalosporins Female Half-Life Injections, Intramuscular Male Pilot Projects
View on PubMed DOI

Development of LC-MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects.

Journal of clinical pharmacy and therapeutics 33201513
WHAT IS KNOWN AND OBJECTIVE: Febuxostat is a well-known drug for treating hyperuricemia and gout. The published methods for determination of febuxostat in human plasma might be unsuitable for high-throughput determination and widespread application. ...
Area Under Curve Chromatography, Liquid Drug Stability Febuxostat Gout Suppressants Half-Life Healthy Volunteers Humans Metabolic Clearance Rate Neural Networks, Computer Reproducibility of Results Tandem Mass Spectrometry
View on PubMed DOI

Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics 32930952
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Adolescent Adult Area Under Curve Asian People Cross-Over Studies Cytochrome P-450 CYP1A1 Deferasirox Drug Compounding Female Glucuronosyltransferase Half-Life Healthy Volunteers Humans Iron Chelating Agents Male Middle Aged Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins Neural Networks, Computer Polymorphism, Genetic Polymorphism, Single Nucleotide Predictive Value of Tests Young Adult
View on PubMed DOI

Predicting Elimination of Small-Molecule Drug Half-Life in Pharmacokinetics Using Ensemble and Consensus Machine Learning Methods.

Journal of chemical information and modeling 38563433
Half-life is a significant pharmacokinetic parameter included in the excretion phase of absorption, distribution, metabolism, and excretion. It is one of the key factors for the successful marketing of drug candidates. Therefore, predicting half-life...
Half-Life Machine Learning Pharmaceutical Preparations Pharmacokinetics Quantitative Structure-Activity Relationship Small Molecule Libraries Support Vector Machine
View on PubMed DOI

Development of machine learning-based quantitative structure-activity relationship models for predicting plasma half-lives of drugs in six common food animal species.

Toxicological sciences : an official journal of the Society of Toxicology 39302735
Plasma half-life is a crucial pharmacokinetic parameter for estimating extralabel withdrawal intervals of drugs to ensure the safety of food products derived from animals. This study focuses on developing a quantitative structure-activity relationshi...
Algorithms Animals Cattle Chickens Goats Half-Life Machine Learning Neural Networks, Computer Quantitative Structure-Activity Relationship Sheep Swine Turkeys Veterinary Drugs
View on PubMed DOI

Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 40113223
Single-time-point (STP) image-based dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared with conventional multiple-time-point image-based dosimetry. Despite numerous advancements, current ST...
Aged Half-Life Humans Machine Learning Male Middle Aged Radiometry Radiopharmaceuticals Time Factors
View on PubMed DOI
Popular Topics
Recent Journals