AIMC Topic: Aminopyridines

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Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BMC cancer May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Randomized Controlled Trials as Topic Cyclin-Dependent Kinase 4 Progression-Free Survival Aminopyridines Cyclin-Dependent Kinase 6 Breast Neoplasms Receptor, ErbB-2 Receptors, Estrogen Antineoplastic Combined Chemotherapy Protocols Network Meta-Analysis as Topic Aromatase Inhibitors Purines Treatment Outcome Protein Kinase Inhibitors Receptors, Progesterone Benzimidazoles Humans Female
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Diversity of approaches in artificial intelligence: an opportunity for discoveries in thoracic imaging.

The European respiratory journal Jul 7, 2022
Quinolones Cystic Fibrosis Aminopyridines Aminophenols Benzodioxoles Artificial Intelligence Tomography, X-Ray Computed Unsupervised Machine Learning Humans
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Artificial intelligence in computed tomography for quantifying lung changes in the era of CFTR modulators.

The European respiratory journal Mar 3, 2022
BACKGROUND: Chest computed tomography (CT) remains the imaging standard for demonstrating cystic fibrosis (CF) airway structural disease . However, visual scoring systems as an outcome measure are time consuming, require training and lack high reprod...
Tomography, X-Ray Computed Reproducibility of Results Young Adult Humans Artificial Intelligence Retrospective Studies Adolescent Child, Preschool Child Adult Middle Aged Lung Aminopyridines Cystic Fibrosis Transmembrane Conductance Regulator
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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics Apr 21, 2021
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Drug Approval Rifampin Folic Acid Antagonists Aminopyridines Tetrahydrofolate Dehydrogenase Benzodioxoles United States Food and Drug Administration Proline Lactams, Macrocyclic Molecular Dynamics Simulation Sulfonamides United States Candida albicans Cyclopropanes Humans Drug Repositioning Molecular Docking Simulation Candidiasis Deep Learning Antifungal Agents
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Molecular docking and machine learning analysis of Abemaciclib in colon cancer.

BMC molecular and cell biology Jul 8, 2020
BACKGROUND: The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised opens the doors to the design ...
Drug Repositioning Algorithms Neoplasm Staging Prognosis Colonic Neoplasms Molecular Docking Simulation Gene Expression Regulation, Neoplastic Humans Adenocarcinoma Gene Expression Profiling Survival Analysis Machine Learning Databases, Protein Gastrointestinal Hormones Cell Line, Tumor Benzimidazoles Epistasis, Genetic Fatty Acid-Binding Proteins Aminopyridines
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Drug-Drug interactions and special considerations in breast cancer patients treated with CDK4/6 inhibitors: A comprehensive review.

Cancer treatment reviews Jun 1, 2025
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have reshaped the treatment paradigm of hormone receptor positive (HR + )/HER2-negative breast cancer in both adjuvant and metastatic settings. However, their metabolism via the cytochrome P450 (CYP3A4...
Pyridines Piperazines Drug Interactions Female Breast Neoplasms Antineoplastic Agents Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Aminopyridines Protein Kinase Inhibitors Benzimidazoles Humans Purines
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