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Gram-Positive Bacterial Infections

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Distribution of main Gram-positive pathogens causing bloodstream infections in United States and European hospitals during the SENTRY Antimicrobial Surveillance Program (2010-2016): concomitant analysis of oritavancin in vitro activity.

Journal of chemotherapy (Florence, Italy) 30843778
This study updates the distribution and trends of Gram-positive organisms causing bloodstream infections (BSIs) in the United States (US) and Europe during 2010-2016. In vitro activities of oritavancin and comparators were also evaluated. Staphylococ...
Anti-Bacterial Agents Bacteremia Cross Infection Europe Gram-Positive Bacteria Gram-Positive Bacterial Infections Hospitals Humans Lipoglycopeptides United States
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In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease 29338931
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Anti-Bacterial Agents Canada Enterobacteriaceae Enterobacteriaceae Infections Epidemiological Monitoring Gram-Negative Bacteria Gram-Negative Bacterial Infections Gram-Positive Bacteria Gram-Positive Bacterial Infections Humans Laboratories, Hospital Microbial Sensitivity Tests Tetracyclines
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Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe.

Diagnostic microbiology and infectious disease 29306582
Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and it is highly active against Gram-positive pathogens including emerging drug-resistant pathogens. In vitro activity of iclaprim and comparators against 2814 Gram-po...
Americas Anti-Bacterial Agents Asia Europe Folic Acid Antagonists Gram-Positive Bacterial Infections Humans Microbial Sensitivity Tests Pyrimidines Staphylococcus aureus Streptococcus
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Determination of Tedizolid susceptibility interpretive criteria for gram-positive pathogens according to clinical and laboratory standards institute guidelines.

Diagnostic microbiology and infectious disease 29277464
For effective antibacterial therapy, physicians require qualitative test results using susceptibility breakpoints provided by clinical microbiology laboratories. This article summarizes the key components used to establish the Clinical Laboratory Sta...
Animals Anti-Bacterial Agents Bacterial Load Enterococcus faecalis Gram-Positive Bacterial Infections Humans Linezolid Mice Microbial Sensitivity Tests Oxazolidinones Staphylococcus aureus Streptococcus agalactiae Streptococcus pyogenes Tetrazoles
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Currently used dosage regimens of vancomycin fail to achieve therapeutic levels in approximately 40% of intensive care unit patients.

Revista Brasileira de terapia intensiva 28099635
OBJECTIVE:: This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possi...
Acute Kidney Injury Adult Aged Anti-Bacterial Agents Creatinine Dose-Response Relationship, Drug Drug Monitoring Female Gram-Positive Bacterial Infections Humans Intensive Care Units Male Middle Aged Prospective Studies Vancomycin
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Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

Kidney international 28318629
The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patients, unequivocal evidence that an individual's immune system distinguishes between different organisms...
Acute Disease Adolescent Adult Aged Aged, 80 and over Area Under Curve Bacteria Biomarkers Case-Control Studies Female Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Host-Pathogen Interactions Humans Machine Learning Male Middle Aged Nonlinear Dynamics Pattern Recognition, Automated Peptide Mapping Peritoneal Dialysis Peritonitis Point-of-Care Systems Point-of-Care Testing Predictive Value of Tests Reproducibility of Results ROC Curve Time Factors Young Adult
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Machine Learning Algorithms Identify Pathogen-Specific Biomarkers of Clinical and Metabolomic Characteristics in Septic Patients with Bacterial Infections.

BioMed research international 32802867
Sepsis is a high-mortality disease that is infected by bacteria, but pathogens in individual patients are difficult to diagnosis. Metabolomic changes triggered by microbial activity provide us with the possibility of accurately identifying infection....
Aged Biomarkers Databases, Factual Diagnosis, Computer-Assisted Female Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Humans Machine Learning Male Middle Aged Sepsis
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Identification of key drivers of antimicrobial resistance in using machine learning.

Canadian journal of microbiology 39079170
With antimicrobial resistance (AMR) rapidly evolving in pathogens, quick and accurate identification of genetic determinants of phenotypic resistance is essential for improving surveillance, stewardship, and clinical mitigation. Machine learning (ML)...
Anti-Bacterial Agents Bacterial Proteins Drug Resistance, Bacterial Enterococcus faecalis Enterococcus faecium Genome, Bacterial Gram-Positive Bacterial Infections Humans Machine Learning Microbial Sensitivity Tests Plasmids
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