AIMC Topic: Gram-Positive Bacterial Infections

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Identification of key drivers of antimicrobial resistance in using machine learning.

Canadian journal of microbiology Jul 30, 2024
With antimicrobial resistance (AMR) rapidly evolving in pathogens, quick and accurate identification of genetic determinants of phenotypic resistance is essential for improving surveillance, stewardship, and clinical mitigation. Machine learning (ML)...
Humans Machine Learning Anti-Bacterial Agents Plasmids Gram-Positive Bacterial Infections Genome, Bacterial Enterococcus faecium Drug Resistance, Bacterial Microbial Sensitivity Tests Bacterial Proteins Enterococcus faecalis
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Machine Learning Algorithms Identify Pathogen-Specific Biomarkers of Clinical and Metabolomic Characteristics in Septic Patients with Bacterial Infections.

BioMed research international Jul 27, 2020
Sepsis is a high-mortality disease that is infected by bacteria, but pathogens in individual patients are difficult to diagnosis. Metabolomic changes triggered by microbial activity provide us with the possibility of accurately identifying infection....
Gram-Negative Bacterial Infections Machine Learning Diagnosis, Computer-Assisted Databases, Factual Sepsis Biomarkers Gram-Positive Bacterial Infections Female Humans Aged Male Middle Aged
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In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease Dec 22, 2017
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Gram-Positive Bacterial Infections Humans Enterobacteriaceae Infections Laboratories, Hospital Enterobacteriaceae Anti-Bacterial Agents Epidemiological Monitoring Tetracyclines Gram-Negative Bacteria Microbial Sensitivity Tests Gram-Negative Bacterial Infections Gram-Positive Bacteria Canada
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Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe.

Diagnostic microbiology and infectious disease Dec 7, 2017
Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and it is highly active against Gram-positive pathogens including emerging drug-resistant pathogens. In vitro activity of iclaprim and comparators against 2814 Gram-po...
Asia Folic Acid Antagonists Streptococcus Gram-Positive Bacterial Infections Pyrimidines Anti-Bacterial Agents Americas Microbial Sensitivity Tests Staphylococcus aureus Europe Humans
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Determination of Tedizolid susceptibility interpretive criteria for gram-positive pathogens according to clinical and laboratory standards institute guidelines.

Diagnostic microbiology and infectious disease Nov 7, 2017
For effective antibacterial therapy, physicians require qualitative test results using susceptibility breakpoints provided by clinical microbiology laboratories. This article summarizes the key components used to establish the Clinical Laboratory Sta...
Anti-Bacterial Agents Animals Microbial Sensitivity Tests Mice Staphylococcus aureus Streptococcus agalactiae Streptococcus pyogenes Humans Enterococcus faecalis Oxazolidinones Bacterial Load Tetrazoles Gram-Positive Bacterial Infections Linezolid
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Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

Kidney international Mar 17, 2017
The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patients, unequivocal evidence that an individual's immune system distinguishes between different organisms...
Middle Aged Case-Control Studies Adolescent Time Factors Adult Male Point-of-Care Systems Acute Disease Point-of-Care Testing Nonlinear Dynamics Pattern Recognition, Automated ROC Curve Bacteria Predictive Value of Tests Area Under Curve Machine Learning Biomarkers Female Reproducibility of Results Aged Peptide Mapping Aged, 80 and over Peritonitis Young Adult Peritoneal Dialysis Host-Pathogen Interactions Gram-Positive Bacterial Infections Humans Gram-Negative Bacterial Infections
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Distribution of main Gram-positive pathogens causing bloodstream infections in United States and European hospitals during the SENTRY Antimicrobial Surveillance Program (2010-2016): concomitant analysis of oritavancin in vitro activity.

Journal of chemotherapy (Florence, Italy) Sep 1, 2018
This study updates the distribution and trends of Gram-positive organisms causing bloodstream infections (BSIs) in the United States (US) and Europe during 2010-2016. In vitro activities of oritavancin and comparators were also evaluated. Staphylococ...
Bacteremia Humans United States Europe Anti-Bacterial Agents Cross Infection Hospitals Gram-Positive Bacteria Gram-Positive Bacterial Infections Lipoglycopeptides
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Currently used dosage regimens of vancomycin fail to achieve therapeutic levels in approximately 40% of intensive care unit patients.

Revista Brasileira de terapia intensiva Jan 1, 2016
OBJECTIVE:: This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possi...
Creatinine Vancomycin Gram-Positive Bacterial Infections Middle Aged Dose-Response Relationship, Drug Drug Monitoring Anti-Bacterial Agents Prospective Studies Acute Kidney Injury Intensive Care Units Female Aged Adult Humans Male
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