AIMC Topic: Benzodioxoles

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Diversity of approaches in artificial intelligence: an opportunity for discoveries in thoracic imaging.

The European respiratory journal Jul 7, 2022
Humans Artificial Intelligence Tomography, X-Ray Computed Unsupervised Machine Learning Quinolones Cystic Fibrosis Aminophenols Aminopyridines Benzodioxoles
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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics Apr 21, 2021
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Humans Molecular Docking Simulation Deep Learning United States Candida albicans Cyclopropanes Drug Repositioning Candidiasis Antifungal Agents Molecular Dynamics Simulation Sulfonamides United States Food and Drug Administration Proline Lactams, Macrocyclic Drug Approval Rifampin Folic Acid Antagonists Aminopyridines Tetrahydrofolate Dehydrogenase Benzodioxoles
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Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury.

Journal of neurophysiology Jan 8, 2020
Our previous work showed that lateral fluid percussion injury to the sensorimotor cortex (SMC) of anesthetized rats increased neuronal synaptic hyperexcitability in layer 5 (L5) neurons in ex vivo brain slices 10 days postinjury. Furthermore, endocan...
Machine Learning Animals Male Rats, Wistar Rats Brain Injuries, Traumatic Piperazines Piperidines Enzyme Inhibitors Carbamates Amidohydrolases Succinimides Benzamides Pyramidal Cells Electrophysiological Phenomena Excitatory Postsynaptic Potentials Sensorimotor Cortex Endocannabinoids Benzodioxoles Monoacylglycerol Lipases
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