AIMC Topic: Hemoglobin, Sickle

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Biophysical Profiling of Sickle Cell Disease Using Holographic Cytometry and Deep Learning.

International journal of molecular sciences Jul 25, 2023
Sickle cell disease (SCD) is an inherited hematological disorder associated with high mortality rates, particularly in sub-Saharan Africa. SCD arises due to the polymerization of sickle hemoglobin, which reduces flexibility of red blood cells (RBCs),...
Humans Deep Learning Anemia, Sickle Cell Erythrocytes Hematologic Diseases Hemoglobin, Sickle
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Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells adhered to laminin.

PLoS computational biology Nov 29, 2021
Sickle cell disease, a genetic disorder affecting a sizeable global demographic, manifests in sickle red blood cells (sRBCs) with altered shape and biomechanics. sRBCs show heightened adhesive interactions with inflamed endothelium, triggering painfu...
Humans Neural Networks, Computer Diagnosis, Computer-Assisted Deep Learning In Vitro Techniques Computational Biology Microfluidics Anemia, Sickle Cell High-Throughput Screening Assays Image Interpretation, Computer-Assisted Biophysical Phenomena Lab-On-A-Chip Devices Laminin Protein Multimerization Erythrocytes, Abnormal Erythrocyte Deformability Hemoglobin, Sickle
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