Solid-state nanopore and nanochannel biosensors have revolutionized protein detection by offering label-free, highly sensitive analyses. Traditional sensing systems (1st and 2nd stages) primarily focus on inner wall (IW) interactions, facing challeng...
Interleukin-6 (IL-6) plays a pivotal role in the inflammatory response of diabetic wounds, providing critical insights for clinicians in the development of personalized treatment strategies. However, the low concentration of IL-6 in biological sample...
Circulating tumor cells (CTCs) are vital indicators of metastasis and provide a non-invasive method for early cancer diagnosis, prognosis, and therapeutic monitoring. However, their low prevalence and heterogeneity in the bloodstream pose significant...
Proteins can act as suitable biomarkers for the prognosis and diagnosis of certain conditions and can help us gain an understanding of the fundamental processes that occur inside an organism. In this work, we present a fully automated machine learnin...
Thrombotic events, such as strokes and deep vein thrombosis, remain a significant global health burden, with traditional diagnostic methods often failing to capture the complex, patient-specific nuances of thrombosis risk. This Perspective explores t...
International journal for numerical methods in biomedical engineering
40273905
Microfluidic devices (MDs) present a novel method for detecting circulating tumor cells (CTCs), enhancing the process through targeted techniques and visual inspection. However, current approaches often yield heterogeneous CTC populations, necessitat...
Microfluidic biosensors offer a promising solution for real-time analysis of coronaviruses with minimal sample volumes. This study optimizes a biochip for the rapid detection of SARS-CoV-2 using the Taguchi orthogonal table L(3), which comprises nine...
Point-of-care testing (POCT) with multiplexed capability, ultrahigh sensitivity, affordable smart devices, and user-friendly operation is critically needed for clinical diagnostics and food safety. This study presents a deep-learning-assisted microfl...
Lung cancer exhibits strong heterogeneity, and its early diagnosis and precise subtyping are of great importance, as they can increase the ability to deliver personalized medicines by tailoring therapy regimens. Tissue biopsy, albeit the gold standar...
The scarcity of human biopsies available for drug testing is a paramount challenge for developing therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation of tissues and fluids offer the ex...