AIMC Topic: Laminin

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Artificial intelligence and the analysis of cryo-EM data provide structural insight into the molecular mechanisms underlying LN-lamininopathies.

Scientific reports Oct 19, 2023
Laminins (Lm) are major components of basement membranes (BM), which polymerize to form a planar lattice on cell surface. Genetic alternations of Lm affect their oligomerization patterns and lead to failures in BM assembly manifesting in a group of h...
Humans Artificial Intelligence Polymers Cryoelectron Microscopy Laminin Basement Membrane
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Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells adhered to laminin.

PLoS computational biology Nov 29, 2021
Sickle cell disease, a genetic disorder affecting a sizeable global demographic, manifests in sickle red blood cells (sRBCs) with altered shape and biomechanics. sRBCs show heightened adhesive interactions with inflamed endothelium, triggering painfu...
Humans Neural Networks, Computer Diagnosis, Computer-Assisted Deep Learning In Vitro Techniques Computational Biology Microfluidics Anemia, Sickle Cell High-Throughput Screening Assays Image Interpretation, Computer-Assisted Biophysical Phenomena Lab-On-A-Chip Devices Laminin Protein Multimerization Erythrocytes, Abnormal Erythrocyte Deformability Hemoglobin, Sickle
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Integrating bioinformatics and machine learning to unravel shared mechanisms and biomarkers in chronic obstructive pulmonary disease and type 2 diabetes.

Postgraduate medical journal May 18, 2025
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are on the rise. While there is evidence of a link between the two diseases, the pathophysiological mechanisms they share are not fully understood.
Humans Machine Learning Biomarkers Pulmonary Disease, Chronic Obstructive Gene Expression Profiling ROC Curve Diabetes Mellitus, Type 2 Computational Biology Matrix Metalloproteinase 9 Laminin
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[Expression of Tim-3 on Peripheral CD56(+) NK Cells and ItsCorrelation with Liver Fibrosis in Patients withAdvanced Schistosomiasis].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases Oct 1, 2015
OBJECTIVE: To explore the expression of T cell immunoglobulin and mucin domain protein 3 (Tim-3) on CD56(+) NK cells in peripheral blood and its correlation with liver fibrosis indicators in patients with advanced schistosomiasis.
Humans Interleukin-4 Case-Control Studies Enzyme-Linked Immunosorbent Assay Liver Cirrhosis Membrane Proteins Peptide Fragments Flow Cytometry Hyaluronic Acid Hepatitis A Virus Cellular Receptor 2 Collagen Type IV Killer Cells, Natural Interferon-gamma Procollagen Laminin Schistosomiasis
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