AIMC Topic: Sarcomeres

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CardioVinci: building blocks for virtual cardiac cells using deep learning.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences Oct 3, 2022
Advances in electron microscopy (EM) such as electron tomography and focused ion-beam scanning electron microscopy provide unprecedented, three-dimensional views of cardiac ultrastructures within sample volumes ranging from hundreds of nanometres to ...
Humans Deep Learning Image Processing, Computer-Assisted Myocytes, Cardiac Electron Microscope Tomography Sarcomeres
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Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy.

Journal of the American Society for Mass Spectrometry Apr 8, 2020
Top-down mass spectrometry (MS) is a powerful tool for the identification and comprehensive characterization of proteoforms arising from alternative splicing, sequence variation, and post-translational modifications. However, the complex data set gen...
Humans Machine Learning Data Analysis Algorithms Sensitivity and Specificity Proteomics Protein Processing, Post-Translational Tandem Mass Spectrometry Alternative Splicing Sarcomeres Muscle Proteins
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Ratchet-integrated pneumatic actuator (RIPA): a large-stroke soft linear actuator inspired by sarcomere muscle contraction.

Bioinspiration & biomimetics Mar 25, 2020
Pneumatic artificial muscles (PAMs) have a wide range of robotics applications, especially in soft robots, for their ability to generate linear force and displacement with the soft, lightweight, compact, and safe characteristics as well as high power...
Humans Algorithms Biomechanical Phenomena Animals Robotics Equipment Design Muscle Contraction Biomimetic Materials Sarcomeres
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Identification of a Multiplex Biomarker Panel for Hypertrophic Cardiomyopathy Using Quantitative Proteomics and Machine Learning.

Molecular & cellular proteomics : MCP Jun 26, 2019
Hypertrophic cardiomyopathy (HCM) is defined by pathological left ventricular hypertrophy (LVH). It is the commonest inherited cardiac condition and a significant number of high risk cases still go undetected until a sudden cardiac death (SCD) event....
Humans Machine Learning Phenotype Prospective Studies Biomarkers Female Aged Young Adult Adult Male Middle Aged Peptides Severity of Illness Index Case-Control Studies Proteomics Predictive Value of Tests Mutation Cardiomyopathy, Hypertrophic Hypertrophy, Left Ventricular Sarcomeres
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