AIMC Topic: Mycobacterium smegmatis
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Machine Learning Assisted Simultaneous Structural Profiling of Differently Charged Proteins in a Porin A (MspA) Electroosmotic Trap.
Journal of the American Chemical Society
Jan 7, 2022
The nanopore is emerging as a means of single-molecule protein sensing. However, proteins demonstrate different charge properties, which complicates the design of a sensor that can achieve simultaneous sensing of differently charged proteins. In this...
Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach.
PLoS computational biology
Mar 29, 2021
To better combat the expansion of antibiotic resistance in pathogens, new compounds, particularly those with novel mechanisms-of-action [MOA], represent a major research priority in biomedical science. However, rediscovery of known antibiotics demons...
Ultrasonic exposure parameters screening in permeability of mycobacterium smegmatis cytoderm induced by cavitation based on artificial neural network identification.
Ultrasonics sonochemistry
May 31, 2019
The low intensity ultrasound has been adopted by researchers to enhance the bactericidal effect against bacteria in vitro and in vivo. Although the mechanism is not completely understood, one dominant opinion is that the permeability increases becaus...
Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I.
Tuberculosis (Edinburgh, Scotland)
Jan 20, 2017
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Machine Learning
Tuberculosis
Molecular Docking Simulation
Molecular Targeted Therapy
Humans
Mycobacterium tuberculosis
Drug Design
Bayes Theorem
Computer-Aided Design
Dose-Response Relationship, Drug
Antitubercular Agents
Topoisomerase I Inhibitors
Mycobacterium smegmatis
Structure-Activity Relationship
Protein Conformation
DNA Topoisomerases, Type I
Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
European journal of medicinal chemistry
Dec 31, 2016
Diaryltriazene derivatives were synthesized and evaluated for their antimicrobial properties. Initial experiments showed some of these compounds to have activity against both methicillin-resistant strains of Staphylococus aureus (MRSA) and Mycobacter...
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