AIMC Topic: NEDD8 Protein

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Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

Scientific reports May 30, 2025
BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, we reported an unexpected role of neddylation inhibitors in desensitizing the therapeutic efficacy of...
Humans Animals Cell Line, Tumor Mice Protein Processing, Post-Translational Drug Resistance, Neoplasm Protein Kinase Inhibitors Fusion Proteins, bcr-abl Leukemia, Myelogenous, Chronic, BCR-ABL Positive Tyrosine Kinase Inhibitors NEDD8 Protein
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Identification of Potential Neddylation-related Key Genes in Ischemic Stroke based on Machine Learning Methods.

Molecular neurobiology Nov 1, 2023
Ischemic stroke (IS) is a complex neurological disease that can lead to severe disability or even death. Understanding the molecular mechanisms involved in the occurrence and progression of IS is of great significance for developing effective treatme...
Humans Machine Learning Gene Expression Profiling Gene Regulatory Networks Databases, Genetic Ischemic Stroke Gene Ontology NEDD8 Protein
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