AIMC Topic: Fusion Proteins, bcr-abl

Clear Filters Showing 1 to 4 of 4 articles

Artificial intelligence-driven label-free detection of chronic myeloid leukemia cells using ghost cytometry.

Scientific reports Jul 1, 2025
Early diagnosis and treatment initiation of chronic myeloid leukemia (CML) are considered to increase the rate of deep molecular response. However, the early diagnosis of CML is challenging due to the absence of clinical symptoms and peripheral blood...
Humans Artificial Intelligence Machine Learning Algorithms Female Male Flow Cytometry Protein Kinase Inhibitors Fusion Proteins, bcr-abl Leukemia, Myelogenous, Chronic, BCR-ABL Positive
View on PubMed DOI

Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

Scientific reports May 30, 2025
BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, we reported an unexpected role of neddylation inhibitors in desensitizing the therapeutic efficacy of...
Humans Animals Cell Line, Tumor Mice Protein Processing, Post-Translational Drug Resistance, Neoplasm Protein Kinase Inhibitors Fusion Proteins, bcr-abl Leukemia, Myelogenous, Chronic, BCR-ABL Positive Tyrosine Kinase Inhibitors NEDD8 Protein
View on PubMed DOI

Utilization of Machine Learning in the Prediction, Diagnosis, Prognosis, and Management of Chronic Myeloid Leukemia.

International journal of molecular sciences Mar 12, 2025
Chronic myeloid leukemia is a clonal hematologic disease characterized by the presence of the Philadelphia chromosome and the BCR::ABL1 fusion protein. Integrating different molecular, genetic, clinical, and laboratory data would improve the diagnost...
Humans Machine Learning Algorithms Prognosis Disease Management Fusion Proteins, bcr-abl Leukemia, Myelogenous, Chronic, BCR-ABL Positive
View on PubMed DOI

[Effects of Sinopodophyllum hexundrum on apoptosis in K562 cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Feb 20, 2016
OBJECTIVE: To investigate the effects of Sinopodophyllum hexundrum on apoptosis in K562 cells.
Humans Cell Proliferation Signal Transduction Apoptosis Caspase 3 Drugs, Chinese Herbal Mitochondria K562 Cells Berberidaceae Fusion Proteins, bcr-abl STAT5 Transcription Factor
View on PubMed DOI
Popular Topics
Recent Journals