BACKGROUND: Positron probes can accurately localize malignant tumors by directly detecting positrons emitted from positron-emitting radiopharmaceuticals that accumulate in malignant tumors. In the conventional method for direct positron detection, mu...
Tumour heterogeneity is one of the critical confounding aspects in decoding tumour growth. Malignant cells display variations in their gene transcription profiles and mutation spectra even when originating from a single progenitor cell. Single-cell a...
Physical and engineering sciences in medicine
Jul 18, 2023
The patient setup technique currently in practice in most radiotherapy departments utilises on-couch cone-beam computed tomography (CBCT) imaging. Patients are positioned on the treatment couch using visual markers, followed by fine adjustments to th...
Precision medicine chooses the optimal drug for a patient by considering individual differences. With the tremendous amount of data accumulated for cancers, we develop an interpretable neural network to predict cancer patient survival based on drug p...
Immunotherapy showed remarkable efficacy in several cancer types. However, the majority of patients do not benefit from immunotherapy. Evaluating tumor heterogeneity and immune status before treatment is key to identifying patients that are more like...
Computer methods and programs in biomedicine
Jul 12, 2023
BACKGROUND AND OBJECTIVE: Generalizable and trustworthy deep learning models for PET/CT image segmentation necessitates large diverse multi-institutional datasets. However, legal, ethical, and patient privacy issues challenge sharing of datasets betw...
BACKGROUND: P4 medicine (predict, prevent, personalize, and participate) is a new approach to diagnosing and predicting diseases on a patient-by-patient basis. For the prevention and treatment of diseases, prediction plays a fundamental role. One of ...
Cancer drug response prediction based on genomic information plays a crucial role in modern pharmacogenomics, enabling individualized therapy. Given the expensive and complexity of biological experiments, computational methods serve as effective tool...
OBJECTIVE: Deep neural network (DNN) techniques have demonstrated significant advantages over regression and some other techniques. In recent studies, DNN-based analysis has been conducted on data with high-dimensional input such as omics measurement...