Prime editing is a versatile genome editing tool but requires experimental optimization of the prime editing guide RNA (pegRNA) to achieve high editing efficiency. Here we conducted a high-throughput screen to analyze prime editing outcomes of 92,423...
The gas sweetening process removes hydrogen sulfide (HS) in an acid gas removal unit (AGRU) to meet the gas sales' specification, known as sweet gas. Monitoring the concentration of HS in sweet gas is crucial to avoid operational and environmental is...
International journal of molecular sciences
Jan 16, 2023
Drug design with machine learning support can speed up new drug discoveries. While current databases of known compounds are smaller in magnitude (approximately 108), the number of small drug-like molecules is estimated to be between 1023 and 1060. Th...
Automated multi-organ segmentation plays an essential part in the computer-aided diagnostic (CAD) of chest X-ray fluoroscopy. However, developing a CAD system for the anatomical structure segmentation remains challenging due to several indistinct str...
Droplet digital PCR (ddPCR) is a technique for absolute quantification of nucleic acid molecules and is widely used in biomedical research and clinical diagnosis. ddPCR partitions the reaction solution containing target molecules into a large number ...
Computer methods and programs in biomedicine
Jan 15, 2023
BACKGROUND AND OBJECTIVES: Automatic segmentation of the cerebral vasculature and aneurysms facilitates incidental detection of aneurysms. The assessment of aneurysm rupture risk assists with pre-operative treatment planning and enables in-silico inv...
Knowledge of surface reflection of an object is essential in many technological fields, including graphics and cultural heritage. Compared to direct multi- or hyper-spectral capturing approaches, commercial RGB cameras allow for a high resolution and...
Contact force control for Unmanned Aerial Manipulators (UAMs) is a challenging issue today. This paper designs a new method to stabilize the UAM system during the formation of contact force with the target. Firstly, the dynamic model of the contact p...
International journal of environmental research and public health
Jan 15, 2023
Audio features are physical features that reflect single or complex coordinated movements in the vocal organs. Hence, in speech-based automatic depression classification, it is critical to consider the relationship among audio features. Here, we prop...
PURPOSE: To compare the performance of 2 relatively recent geometric deep learning techniques in diagnosing glaucoma from a single optical coherence tomographic (OCT) scan of the optic nerve head (ONH); and to identify the 3-dimensional (3D) structur...
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