AIMC Topic: Nucleotides

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Deep Learning Approaches for Detection of Breast Adenocarcinoma Causing Carcinogenic Mutations.

International journal of molecular sciences Sep 29, 2022
Genes are composed of DNA and each gene has a specific sequence. Recombination or replication within the gene base ends in a permanent change in the nucleotide collection in a DNA called mutation and some mutations can lead to cancer. Breast adenocar...
Nucleotides Carcinogens Adenocarcinoma Mutation Humans Female Breast Neoplasms Male Deep Learning
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DLm6Am: A Deep-Learning-Based Tool for Identifying N6,2'-O-Dimethyladenosine Sites in RNA Sequences.

International journal of molecular sciences Sep 20, 2022
N6,2'-O-dimethyladenosine (mAm) is a post-transcriptional modification that may be associated with regulatory roles in the control of cellular functions. Therefore, it is crucial to accurately identify transcriptome-wide mAm sites to understand under...
RNA, Messenger Nucleotides Base Sequence Algorithms Deep Learning
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Predicting RNA solvent accessibility from multi-scale context feature via multi-shot neural network.

Analytical biochemistry Jul 7, 2022
Knowledge of RNA solvent accessibility has recently become attractive due to the increasing awareness of its importance for key biological process. Accurately predicting the solvent accessibility of RNA is crucial for understanding its 3D structure a...
RNA Solvents Neural Networks, Computer Nucleotides
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Identification of DNA N4-methylcytosine sites based on multi-source features and gradient boosting decision tree.

Analytical biochemistry May 21, 2022
N4-methylcytosine (4 mC) is an important and common methylation which widely exists in prokaryotes. It plays a crucial role in correcting DNA replication errors and protecting host DNA against degradation by restrictive enzymes. Hence, the accurate i...
Decision Trees DNA Nucleotides Computational Biology Support Vector Machine
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FCNGRU: Locating Transcription Factor Binding Sites by Combing Fully Convolutional Neural Network With Gated Recurrent Unit.

IEEE journal of biomedical and health informatics Apr 14, 2022
Deciphering the relationship between transcription factors (TFs) and DNA sequences is very helpful for computational inference of gene regulation and a comprehensive understanding of gene regulation mechanisms. Transcription factor binding sites (TFB...
Nucleotides Binding Sites Transcription Factors DNA Humans Neural Networks, Computer Protein Binding Computational Biology
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Inferring RNA-binding protein target preferences using adversarial domain adaptation.

PLoS computational biology Feb 24, 2022
Precise identification of target sites of RNA-binding proteins (RBP) is important to understand their biochemical and cellular functions. A large amount of experimental data is generated by in vivo and in vitro approaches. The binding preferences det...
Acclimatization Binding Sites RNA-Binding Proteins Nucleotides Neural Networks, Computer
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Using k-mer embeddings learned from a Skip-gram based neural network for building a cross-species DNA N6-methyladenine site prediction model.

Plant molecular biology Nov 29, 2021
This study used k-mer embeddings as effective feature to identify DNA N6-Methyladenine sites in plant genomes and obtained improved performance without substantial effort in feature extraction, combination and selection. Identification of DNA N6-meth...
Neural Networks, Computer Nucleotides Base Sequence Algorithms Models, Biological DNA, Plant Adenine Surveys and Questionnaires ROC Curve Plants Databases, Genetic
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Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1 infected patients: 336-week rollover study of phase 2b and 3 clinical studies.

Antiviral therapy Nov 26, 2021
BACKGROUND: To evaluate the long-term safety and efficacy of rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), in combination with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in human immunodeficiency vir...
HIV-1 Reverse Transcriptase Inhibitors Anti-HIV Agents Humans Rilpivirine Nucleotides Nucleosides HIV Infections
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iPromoter-ET: Identifying promoters and their strength by extremely randomized trees-based feature selection.

Analytical biochemistry Aug 10, 2021
Promoter is a region of DNA that determines the transcription of a particular gene. There are several σ factors in the RNA polymerase, which has the function of identifying the promoter and facilitating the binding of the RNA polymerase to the promot...
Promoter Regions, Genetic DNA Nucleotides Support Vector Machine Sequence Analysis, DNA
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Infrared Metasurface Augmented by Deep Learning for Monitoring Dynamics between All Major Classes of Biomolecules.

Advanced materials (Deerfield Beach, Fla.) Feb 22, 2021
Insights into the fascinating molecular world of biological processes are crucial for understanding diseases, developing diagnostics, and effective therapeutics. These processes are complex as they involve interactions between four major classes of b...
Sucrose Deep Learning Infrared Rays Nucleotides Liposomes Proteins Lab-On-A-Chip Devices Nucleic Acids Spectrophotometry, Infrared
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