AIMC Topic: Oligodeoxyribonucleotides

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Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning.

Scientific reports Feb 26, 2019
Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated "base editing" being limited to certain nucleotide changes, and only achievable within a small window ar...
Machine Learning Animals Mice Mice, Inbred C57BL CRISPR-Cas Systems Mutation Gene Editing DNA Breaks, Double-Stranded DNA Repair RNA, Guide, CRISPR-Cas Systems Oligodeoxyribonucleotides
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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Humans Female Animals Mice Nanoparticles Mice, Inbred BALB C Mast Cells Adjuvants, Immunologic Influenza Vaccines Orthomyxoviridae Infections Administration, Intranasal Oligodeoxyribonucleotides Hemagglutinin Glycoproteins, Influenza Virus Toll-Like Receptor 9
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